Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Microwave Promoted Hydrolysis of Esters Absorbed on Alumina: A New Deprotection Method for Pivaloyl Groups
– Synlett
(1993)
1993,
793
(doi: 10.1055/s-1993-22612)
Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran.
– Tetrahedron Letters
(1993)
34,
5649
Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage.
– Tetrahedron
(1993)
49,
1675
Some alkylation and reductive amination studies of β-ketomacrolides as potential metal speciation materials
– Heterocycles
(1993)
35,
263
(doi: 10.3987/com-92-s12)
DISPIROKETALS IN SYNTHESIS .3. SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES
– Synthesis
(1993)
1993,
689
(doi: 10.1055/s-1993-25923)
UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA
– Journal of Insect Physiology
(1993)
39,
935
(doi: 10.1016/0022-1910(93)90003-a)
Alfred bader [2]
– Chemical and Engineering News
(1992)
70,
2
Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene
– Synlett
(1992)
1992,
997
(doi: 10.1055/s-1992-21561)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .12. USE OF SILICON AS A CONTROL ELEMENT IN THE SYNTHESIS OF A HIGHLY FUNCTIONALIZED DECALIN FRAGMENT OF AZADIRACHTIN
– J CHEM SOC PERK T 1
(1992)
2735
(doi: 10.1039/p19920002735)
Chemistry of insect antifeedants from Azadirachta indica, Part 14: Absolute configuration of azadirachtin
– Chemical Communications
(1992)
1304
(doi: 10.1039/c39920001304)
- <
- 84 of 105