Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Dispiroketals in Synthesis (Part 22)1: Use of Chiral 2,2′-Bis(phenylthiomethyl)-dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
– Synlett
(1996)
1996,
791
(doi: 10.1055/s-1996-5522)
Direct protection of 1,2-diols from alpha-diketones
– Synlett
(1996)
1996,
793
(doi: 10.1055/s-1996-5523)
Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes
– Chemical Communications
(1996)
317
(doi: 10.1039/CC9960000317)
Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of pi-allyltricarbonyliron lactone complexes
– Chemical Communications
(1996)
657
(doi: 10.1039/CC9960000657)
Autoradiographic localization of [22,23-3H2] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility
– Tissue Cell
(1996)
28,
725
Dispiroketals in synthesis .21. Use of chiral 2,2'-bis(halomethyl)dihydropyrans as new protecting and resolving agents for 1,2-diols
– Synlett
(1996)
1996,
789
(doi: 10.1055/s-1996-5521)
Dispiroketals: a new functional group for organic synthesis
– Contemporary Organic Synthesis
(1995)
2,
365
(doi: 10.1039/co9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
– Bioorganic and Medicinal Chemistry Letters
(1995)
5,
2637
(doi: 10.1016/0960-894x(95)00469-a)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
– SYNLETT
(1995)
1196
SOLID-PHASE SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES VIA TANDEM MICHAEL ADDITION-REACTIONS AND SUBSEQUENT REDUCTIVE AMINATION
– Synlett
(1995)
1995,
1017
(doi: 10.1055/s-1995-5164)
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