Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE CYCLOHEXYL C33-C42 FRAGMENT AND FURTHER COUPLING TO AFFORD THE C22-C42 CARBON UNIT
Tetrahedron Letters
(1994)
35
2091
DISPIROKETALS IN SYNTHESIS .6. HIGHLY STEREOSELECTIVE ALKYLATION OF DISPIROKETAL PROTECTED LACTATE AND GLYCOLATE ENOLATES
Tetrahedron Letters
(1994)
35
769
TOWARDS THE SYNTHESIS OF THE C-37-C-42 FRAGMENT OF RAPAMYCIN - INTRAMOLECULAR REACTIONS OF ALLYL SILANES WITH OXONIUM IONS GENERATED FROM ALPHA-ALKOXY SULFONES
Tetrahedron
(1994)
50
835
Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase
Tetrahedron Letters
(1994)
35
307
2 NEW ROUTES TO THE C19-C26 TETRAHYDROFURAN FRAGMENT OF THE ACYL TETRONIC ACID IONOPHORE TETRONASIN (ICI M139603)
Tetrahedron Letters
(1994)
35
319
BIOSYNTHESIS OF TETRONASIN .3. PREPARATION OF DEUTERIUM-LABELED TRIKETIDES AND TETRAKETIDES AS PUTATIVE BIOSYNTHETIC PRECURSORS OF TETRONASIN
Tetrahedron Letters
(1994)
35
315
Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)
Tetrahedron Letters
(1994)
35
323
Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase
Tetrahedron Letters
(1994)
35
311
"Connectivist" approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin
Tetrahedron
(1994)
50
12267
Dispiroketals in Synthesis (Part 15): Simultaneous Enantioselective and Regioselective Protection of Glycerol by Reaction with C2Symmetric (4S,4′S)-Dimethyl-bis-dihydropyran
Synthesis
(1994)
1994
1275
(doi: 10.1055/s-1994-25680)
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