Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Dispiroketals in synthesis (part 9): Resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran.
Tetrahedron Asymmetry
(1994)
5
553
(doi: 10.1016/0957-4166(94)80016-2)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .16. SYNTHESIS OF SEVERAL DERIVATIVES OF AZADIRACHTIN CONTAINING FLUORESCENT OR IMMUNOGENIC REPORTER GROUPS
Tetrahedron
(1994)
50
8871
Chemistry of insect antifeedants from Azadirachta indica (Part 17): Synthesis of model compounds of azadirachtin. Unusual effect of remote substituents on the course of the oxidative ring contraction reaction.
Tetrahedron
(1994)
50
11553
"Connectivist" approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin
Tetrahedron
(1994)
50
12267
Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis
Synthesis
(1994)
1994
639
(doi: 10.1055/s-1994-25538)
Dispiroketals in Synthesis (Part 15): Simultaneous Enantioselective and Regioselective Protection of Glycerol by Reaction with C2 Symmetric (4S,4′S)-Dimethyl-bis-dihydropyran
Synthesis
(1994)
1994
1275
(doi: 10.1055/s-1994-25680)
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
Tetrahedron Letters
(1994)
35
769
Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates
Tetrahedron Letters
(1994)
35
773
Dispiroketals in synthesis (part 8): Regioselective protection of D-glucopyranose substrates
Tetrahedron Letters
(1994)
35
777
Selective acylation and alkylation reactions of diols using dibutyltin dimethoxide
Synlett
(1993)
1993
913
(doi: 10.1055/s-1993-22650)
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