Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Solid Phase Synthesis of Bicyclo[22.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
– Synlett
(1995)
1995,
1017
(doi: 10.1055/s-1995-5164)
DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS
– Tetrahedron: Asymmetry
(1995)
6,
2403
(doi: 10.1016/0957-4166(95)00318-J)
Dispiroketals in synthesis (Part 18) 1 : Regioselective and enantioselective protection of symmetric polyol substrates using an enantiopure (2 S,2' S)-Dimethyl- bis -dihydropyran
– Synlett
(1995)
1995,
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210,
24
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
– Tetrahedron
(1995)
51,
7755
(doi: 10.1016/0040-4020(95)00395-O)
The synthesis and assay of radiolabelled benzene derivatives
– Tetrahedron
(1995)
51,
7741
(doi: 10.1016/0040-4020(95)00394-N)
Tuning the reactivity of glycosides: Efficient one-pot oligosaccharide synthesis
– Synlett
(1995)
1995,
781
(doi: 10.1055/s-1995-5052)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
– SYNLETT
(1995)
781
Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin
– Tetrahedron
(1995)
51,
6591
(doi: 10.1016/0040-4020(95)00297-l)
BIOSYNTHESIS OF TETRONASIN .4. PREPARATION OF DEUTERIUM-LABELED C19-C26, C17-C26, C-11-C26 AND C3-C26 POLYKETIDE FRAGMENTS AS PUTATIVE BIOSYNTHETIC PRECURSORS OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)
– Tetrahedron
(1995)
51,
5417
(doi: 10.1016/0040-4020(95)00201-I)
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