Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Direct protection of 1,2-diols from alpha-diketones
– Synlett
(1996)
1996,
793
(doi: 10.1055/s-1996-5523)
Synthetic studies towards the clerodane insect antifeedant jodrellin A: Preparation of a polycyclic model compound with antifeedant activity
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1996)
611
(doi: 10.1039/P19960000611)
Dispiroketals in Synthesis (Part 22)1: Use of Chiral 2,2’-Bis(phenylthiomethyl)dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
– Synlett
(1996)
1996,
791
(doi: 10.1055/s-1996-5522)
Dispiroketals in Synthesis (Part 20)1: Preparation of Chiral 2,2’-Bis(halomethyl) and 2,2’-Bis(phenylthiomethyl)dihydropyrans
– Synlett
(1996)
1996,
787
(doi: 10.1055/s-1996-5520)
Autoradiographic localization of [22,23-3H2] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility
– Tissue Cell
(1996)
28,
725
Diastereoselective additions to aldehyde groups in the side-chain of pi-allyltricarbonyliron lactone complexes
– Chem. Commun.
(1996)
317
(doi: 10.1039/cc9960000317)
Dispiroketals in synthesis .21. Use of chiral 2,2'-bis(halomethyl)dihydropyrans as new protecting and resolving agents for 1,2-diols
– Synlett
(1996)
1996,
789
(doi: 10.1055/s-1996-5521)
Dispiroketals: A new functional group for organic synthesis
– Journal of the Chemical Society Perkin Transactions 1
(1995)
2,
365
(doi: 10.1039/co9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
– Bioorganic & Medicinal Chemistry Letters
(1995)
5,
2637
(doi: 10.1016/0960-894X(95)00469-A)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
– SYNLETT
(1995)
1196
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