Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .18. DEMETHYLATION AND METHYLATION OF THE C-8 POSITION OF THE DECALIN PORTION OF AZADIRACHTIN
Tetrahedron
(1995)
51
2077
(doi: 10.1016/0040-4020(94)01071-7)
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Tetrahedron Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-J)
Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex
J. Chem. Soc., Chem. Commun.
(1995)
1751
(doi: 10.1039/c39950001751)
Behavioural responses of locusts and Spodoptera littoralis to azadirachtin and azadirachtin analogues containing fluorescent and immunogenic reporter groups
Journal of Insect Physiology
(1995)
41
555
(doi: 10.1016/0022-1910(95)00014-L)
"Connectivist" approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin
Tetrahedron
(1994)
50
12267
DISPIROKETALS IN SYNTHESIS .14. FUNCTIONALIZED DISPIROKETALS AS NEW CHIRAL AUXILIARIES - HIGHLY STEREOSELECTIVE MICHAEL ADDITIONS TO A BIFUNCTIONAL, C-2-SYMMETRICAL CHIRAL AUXILIARY
Tetrahedron Letters
(1994)
35
7455
(doi: 10.1016/0040-4039(94)85340-1)
Dispiroketals in synthesis (Part 11): Concomitant enantioselective and regioselective protection of 2,5- dibenzoyl-myo-inositol
Tetrahedron Letters
(1994)
35
7443
(doi: 10.1016/0040-4039(94)85337-1)
Dispiroketals in synthesis (Part 12): Functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form
Tetrahedron Letters
(1994)
35
7447
(doi: 10.1016/0040-4039(94)85338-x)
DISPIROKETALS IN SYNTHESIS .13. FUNCTIONALIZED DISPIROKETALS AS NEW CHIRAL AUXILIARIES - HIGHLY STEREOSELECTIVE DIELS-ALDER REACTIONS USING A BIFUNCTIONAL, C-2-SYMMETRICAL CHIRAL AUXILIARY
Tetrahedron Letters
(1994)
35
7451
(doi: 10.1016/0040-4039(94)85339-8)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .17. SYNTHESIS OF MODEL COMPOUNDS OF AZADIRACHTIN - UNUSUAL EFFECT OF REMOTE SUBSTITUENTS ON THE COURSE OF THE OXIDATIVE RING CONTRACTION REACTION
Tetrahedron
(1994)
50
11553
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