Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTR PAP AM CHEM S
(1995)
210
24
The synthesis and assay of radiolabelled benzene derivatives
Tetrahedron
(1995)
51
7741
(doi: 10.1016/0040-4020(95)00394-n)
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
Tetrahedron
(1995)
51
7755
(doi: 10.1016/0040-4020(95)00395-O)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
SYNLETT
(1995)
781
Tuning the Reactivity of Glycosides: Efficient One-pot Oligosaccharide Synthesis1
Synlett
(1995)
1995
781
(doi: 10.1055/s-1995-5052)
Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin
Tetrahedron
(1995)
51
6591
(doi: 10.1016/0040-4020(95)00297-L)
Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)
Tetrahedron
(1995)
51
5417
(doi: 10.1016/0040-4020(95)00201-i)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .18. DEMETHYLATION AND METHYLATION OF THE C-8 POSITION OF THE DECALIN PORTION OF AZADIRACHTIN
Tetrahedron
(1995)
51
2077
(doi: 10.1016/0040-4020(94)01071-7)
Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex
J. Chem. Soc., Chem. Commun.
(1995)
1751
(doi: 10.1039/c39950001751)
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