Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Tetrahedron Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
SOLID-PHASE SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES VIA TANDEM MICHAEL ADDITION-REACTIONS AND SUBSEQUENT REDUCTIVE AMINATION
Synlett
(1995)
1995
1017
(doi: 10.1055/s-1995-5164)
Dispiroketals in Synthesis (Part 18)1: Regioselective and Enantioselective Protection of Symmetric Polyol Substrates Using an Enantiopure (2S,2’S)-Dimethyl-bis-dihydropyran
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTR PAP AM CHEM S
(1995)
210
24
The synthesis and assay of radiolabelled benzene derivatives
Tetrahedron
(1995)
51
7741
(doi: 10.1016/0040-4020(95)00394-N)
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
Tetrahedron
(1995)
51
7755
(doi: 10.1016/0040-4020(95)00395-O)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
SYNLETT
(1995)
781
Tuning the reactivity of glycosides: Efficient one-pot oligosaccharide synthesis
Synlett
(1995)
1995
781
(doi: 10.1055/s-1995-5052)
Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin
Tetrahedron
(1995)
51
6591
(doi: 10.1016/0040-4020(95)00297-L)
Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)
Tetrahedron
(1995)
51
5417
(doi: 10.1016/0040-4020(95)00201-I)
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