Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes
Chemical Communications
(1996)
317
(doi: 10.1039/cc9960000317)
Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of pi-allyltricarbonyliron lactone complexes
Chem. Commun.
(1996)
657
(doi: 10.1039/cc9960000657)
Autoradiographic localization of [22,23-H-3(2)] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility
Tissue Cell
(1996)
28
725
Dispiroketals in Synthesis (Part 20) 1: Preparation of Chiral 2,2′-Bis(halomethyl) and 2,2′-Bis(phenylthiomethyl)dihydropyrans
Synlett
(1996)
1996
787
(doi: 10.1055/s-1996-5520)
Dispiroketals in Synthesis (Part 21)1: Use of Chiral 2,2′-Bis(halomethyl)dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
Synlett
(1996)
1996
789
(doi: 10.1055/s-1996-5521)
Dispiroketals in Synthesis (Part 22)1: Use of Chiral 2,2’-Bis(phenylthiomethyl)dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
Synlett
(1996)
1996
791
(doi: 10.1055/s-1996-5522)
Dispiroketals: a new functional group for organic synthesis
Contemporary Organic Synthesis
(1995)
2
365
(doi: 10.1039/co9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
Bioorganic & Medicinal Chemistry Letters
(1995)
5
2637
(doi: 10.1016/0960-894x(95)00469-a)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
SYNLETT
(1995)
1196
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