Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The synthesis and assay of radiolabelled benzene derivatives
Tetrahedron
(1995)
51
7741
(doi: 10.1016/0040-4020(95)00394-n)
Tuning the Reactivity of Glycosides: Efficient One-pot Oligosaccharide Synthesis1
Synlett
(1995)
1995
781
(doi: 10.1055/s-1995-5052)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
SYNLETT
(1995)
781
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .19. A POTENTIAL RELAY ROUTE FOR THE SYNTHESIS OF AZADIRACHTIN
Tetrahedron
(1995)
51
6591
(doi: 10.1016/0040-4020(95)00297-l)
BIOSYNTHESIS OF TETRONASIN .4. PREPARATION OF DEUTERIUM-LABELED C19-C26, C17-C26, C-11-C26 AND C3-C26 POLYKETIDE FRAGMENTS AS PUTATIVE BIOSYNTHETIC PRECURSORS OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)
Tetrahedron
(1995)
51
5417
(doi: 10.1016/0040-4020(95)00201-i)
Chemistry of insect antifeedants from Azadirachta Indica (part 18): Demethylation and methylation of the C-8 position of the decalin portion of azadirachtin
Tetrahedron
(1995)
51
2077
(doi: 10.1016/0040-4020(94)01071-7)
Synthesis of β-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a π-allyltricarbonyliron lactone complex
Chemical Communications
(1995)
1751
(doi: 10.1039/c39950001751)
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Tetrahedron Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-J)
Behavioural responses of locusts and Spodoptera littoralis to azadirachtin and azadirachtin analogues containing fluorescent and immunogenic reporter groups
Journal of Insect Physiology
(1995)
41
555
(doi: 10.1016/0022-1910(95)00014-L)
Dispiroketals in synthesis (Part 13): Functionalised dispiroketals as new chiral auxiliaries; highly stereoselective diels-alder reactions using a bifunctional, C2- symmetrical chiral auxiliary
Tetrahedron Letters
(1994)
35
7451
(doi: 10.1016/0040-4039(94)85339-8)
- ‹ previous
- Page 77
