Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
One-pot synthesis of tetra- and pentasaccharides from monomeric building blocks using the principles of orthogonality and reactivity tuning
– Synlett
(1997)
1997,
257
(doi: 10.1055/s-1997-765)
Identification of Azadirachtin in Tissue-Cultured Cells of Neem (Azadirachta Indica)
– Natural Product Research
(1997)
10,
95
(doi: 10.1080/10575639708043721)
Direct protection of 1,2-diols from alpha-diketones (pg 793, 1996)
– SYNLETT
(1996)
932
Dispiroketals in synthesis .22. Use of chiral 2,2'-bis(phenylthiomethyl)dihydropyrans as new protecting and resolving agents for 1,2-diols (pg 791, 1996)
– SYNLETT
(1996)
932
Chemistry of insect antifeedants from Azadirachta indica (part 21): synthesis of model compounds of azadirachtin using a decalin framework as a functional group scaffolding
– Journal of the Chemical Society, Perkin Transactions 1
(1996)
1523
(doi: 10.1039/p19960001523)
Chemistry of insect antifeedants from Azadirachta indica .20. Synthesis of biologically active, simple analogues of azadirachtin, containing the hydroxytetrahydrofurancarboxylate hemiketal moiety
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1996)
1517
(doi: 10.1039/p19960001517)
Synthesis and chemistry of the ionophore antibiotic tetronasin
– Farmaco (Societa chimica italiana : 1989)
(1996)
51,
147
(π-Allyl)tricarbonyliron Lactone Complexes in Organic Synthesis: A Useful and Conceptually Unusual Route to Lactones and Lactams
– Chemical reviews
(1996)
96,
423
(doi: 10.1021/cr950015t)
Dispiroketals in Synthesis (Part 20)1: Preparation of Chiral 2,2’-Bis(halomethyl) and 2,2’-Bis(phenylthiomethyl)dihydropyrans
– Synlett
(1996)
1996,
787
(doi: 10.1055/s-1996-5520)
Synthetic studies towards the clerodane insect antifeedant jodrellin A: preparation of a polycyclic model compound with antifeedant activity
– J CHEM SOC PERK T 1
(1996)
611
(doi: 10.1039/P19960000611)
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