Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Polymer supported reagents in synthesis: preparation of bicyclo[2.2.2] octane derivates via Tandem Michael addition reactions and subsequent combinatorial decoration.
– Journal of Combinatorial Chemistry
(2000)
2,
104
(doi: 10.1021/cc9900697)
Rapid assembly of oligosaccharides: 1,2-diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
– Tetrahedron: Asymmetry
(2000)
11,
173
A short and efficient stereoselective synthesis of the polyhydroxylated macrolactone (+)-aspicillin
– Organic letters
(2000)
2,
123
(doi: 10.1021/ol991214s)
METHYL 2,3-O-(6,6'-OCTAHYDRO-6,6'-BI-2H-PYRAN-2,2'-DIYL)-a-D-GALACTOPYRANOSIDE
– Organic Syntheses
(2000)
77,
212
(doi: 10.15227/orgsyn.077.0212)
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
3645
(doi: 10.1039/b003129l)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
– Chemtracts
(2000)
13,
66
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A Convenient Hydroxymethyl Anion Equivalent
– Synlett
(2000)
2000,
455
(doi: 10.1055/s-2000-6559)
Asymmetric molybdenum-catalyzed allylic substitution.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219,
U132
A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977
– Synthetic Communications
(2000)
30,
1955
(doi: 10.1080/00397910008087245)
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