Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]

SV Ley, HMI Osborn

– Organic Syntheses

(2000)

77,

212

A short stereoselective total synthesis of the fusarium toxin equisetin.

LT Burke, DJ Dixon, SV Ley, F Rodríguez

– Organic letters

(2000)

2,

3611

(doi: 10.1021/ol006493u)

The total synthesis of the annonaceous acetogenin, muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

– Angewandte Chemie

(2000)

39,

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::AID-ANIE3622>3.0.CO;2-H)

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

– Angewandte Chemie (International ed. in English)

(2000)

39,

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::aid-anie3622>3.0.co;2-h)

Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V

A Düffels, LG Green, R Lenz, SV Ley, SP Vincent, CH Wong

– Bioorganic & Medicinal Chemistry

(2000)

8,

2519

(doi: 10.1016/s0968-0896(00)00187-5)

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

IR Baxendale, SV Ley

– Bioorganic & Medicinal Chemistry Letters

(2000)

10,

1983

(doi: 10.1016/S0960-894X(00)00383-8)

Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species

P Grice, AG Leach, SV Ley, A Massi, DM Mynett

– J Comb Chem

(2000)

2,

491

(doi: 10.1021/cc000021p)

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferases

MD Burkart, SP Vincent, A Düffels, BW Murray, SV Ley, CH Wong

– Bioorganic & medicinal chemistry

(2000)

8,

1937

(doi: 10.1016/s0968-0896(00)00139-5)

Synthesis of high-mannose type neoglycolipids: Active targeting of liposomes to macrophages in gene therapy

A Düffels, LG Green, SV Ley, AD Miller

– Chemistry A European Journal

(2000)

6,

1416

(doi: 10.1002/(sici)1521-3765(20000417)6:8<1416::aid-chem1416>3.0.co;2-o)

Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.

AV Malkov, IR Baxendale, M Bella, V Langer, P Kocovsky

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2000)

219,

U132

(link to publication)