Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of Glycans from the Glycodelins: Two Undeca‐, Two Deca‐, Three Nona‐, an Octa‐ and a Heptasaccharide
– Chemistry - A European Journal
(1999)
5,
3326
Highly cis- or trans-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers
– Journal of the Chemical Society Perkin Transactions 1
(1999)
2665
(doi: 10.1039/a904891j)
Modified mesoporous silicate MCM-41 materials: immobilised perruthenate—a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen
– Chemical Communications
(1999)
1907
(doi: 10.1039/a906354d)
Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents
– J CHEM SOC PERK T 1
(1999)
2421
(doi: 10.1039/a904384e)
π-allyltricarbonyliron lactone complexes in a diastereoselective Mukaiyama aldol reaction.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1999)
218,
U51
Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid
– Journal of the Chemical Society - Perkin Transactions 1
(1999)
2231
(doi: 10.1039/a904921e)
Use of the potassium ion as a template for the selective derivatization of the antibiotic X-206
– The Journal of Organic Chemistry
(1999)
64,
6252
(doi: 10.1021/jo9903151)
Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex
– Journal of the Chemical Society Perkin Transactions 1
(1999)
1917
(doi: 10.1039/a903641e)
Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents.
– Bioorganic & Medicinal Chemistry Letters
(1999)
9,
2049
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