Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Polymer-supported hypervalent iodine reagents in 'clean' organic synthesis with potential application in combinatorial chemistry
Journal of the Chemical Society Perkin Transactions 1
(1999)
669
(doi: 10.1039/a809799b)
Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution.
The Journal of Organic Chemistry
(1999)
64
2737
(doi: 10.1021/jo9821776)
Molybdenum(II)-catalyzed allylation of electron-rich aromatics and heteroaromatics
The Journal of Organic Chemistry
(1999)
64
2751
(doi: 10.1021/jo982178y)
1,7-Induction of chirality in Mukaiyama aldol reactions using π- allyltricarbonyliron lactone and lactam complexes as chiral templates
Tetrahedron
(1999)
55
3515
Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis
Journal of the Chemical Society Perkin Transactions 1
(1999)
375
(doi: 10.1039/a809798d)
Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
107
(doi: 10.1039/a809345h)
Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei.
Angew Chem Int Ed Engl
(1999)
37
3423
Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin
AZADIRACHTA INDICA A. JUSS.
(1999)
247
Chemistry of Insect Antifeedants from Azadirachta indica (Part 22): Functionalisation of the Decalin Fragment of Azadirachtin via a Claisen Rearrangement Reaction
Synlett
(1999)
1999
1295
(doi: 10.1055/s-1999-2802)
Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR
Chemtracts
(1999)
12
539
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