Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR

SK Latypov, JM Seco, E Quinoa, R Riguera, E Fernandez-Megia, SV Ley

Chemtracts

(1999)

539

Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents

J Habermann, SV Ley, JJ Scicinski, JS Scott, R Smits, AW Thomas

Journal of the Chemical Society Perkin Transactions 1

(1999)

2425

(doi: 10.1039/a905616e)

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1999)

1253

(doi: 10.1039/a901802f)

Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin

AJ Mordue, AJ Nisbet, L Jennens, SV Ley, W Mordue

AZADIRACHTA INDICA A. JUSS.

(1999)

247

Chemistry of insect antifeedants from Azadirachta indica (Part 22): Functionalisation of the decalin fragment of azadirachtin via a Claisen rearrangement reaction

SV Ley*, CE Gutteridge, AR Pape, CD Spilling, C Zumbrunn

Synlett

(1999)

1999

1295

(doi: 10.1055/s-1999-2802)

Assembly of dendritic glycoclusters from monomeric mannose building blocks

P Langer, SJ Ince, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1998)

3913

(doi: 10.1039/a807621i)

Total synthesis of the protein phosphatase inhibitor okadaic acid

SV Ley, AC Humphries, H Eick, R Downham, AR Ross, RJ Boyce, JBJ Pavey, J Pietruszka

Journal of the Chemical Society, Perkin Transactions 1

(1998)

3907

(doi: 10.1039/a807957i)

Characterization of azadirachtin binding to Sf9 nuclei in vitro

AJ Nisbet, AJ Mordue, RB Grossman, L Jennens, SV Ley, W Mordue

Archives of Insect Biochemistry and Physiology

(1998)

461

(doi: 10.1002/(SICI)1520-6327(1997)34:4<461::AID-ARCH5>3.0.CO;2-V)

Total synthesis of roflamycoin, an oxopolyene macrolide antibiotic

SD Rychnovsky, UR Khire, G Yang, SV Ley, P Jones

Chemtracts

(1998)

1005

Double diastereodifferentiation in the Mukaiyama aldol reactions of π-allyltricarbonyliron lactone complexes: 1,7- vs . 1,2-asymmetric induction

SV Ley, LR Cox, JM Worrall

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1998)

3349

(doi: 10.1039/a805996i)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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