Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Use of the Potassium Ion as a Template for the Selective Derivatization of the Antibiotic X-206
– The Journal of Organic Chemistry
(1999)
64,
6252
(doi: 10.1021/jo9903151)
Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
1917
(doi: 10.1039/a903641e)
Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents.
– Bioorg Med Chem Lett
(1999)
9,
2049
A general and efficient procedure for the preparation of enantiopure anti-1,2-diols - synthesis and utility of (R ',R ',S,R)-2,3-butane diacetal protected butane tetrol
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
1635
(doi: 10.1039/a902732g)
Dispiroketals in synthesis. Part 25. Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols
– Journal of the Chemical Society Perkin Transactions 1
(1999)
1647
(doi: 10.1039/a900951e)
Preparation of desymmetrised meso -tartrate derivatives—synthesis and utility of ( R′ , R′ , R , S )-2,3-butane diacetal protected dimethyl tartrate
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
1631
(doi: 10.1039/a902733e)
New building blocks for efficient and highly diastereoselective polyol production-synthesis and utility of (R',R',S,S) and (S",S",R,R)-2,3-butane diacetal protected butane tetrol derivatives
– J CHEM SOC PERK T 1
(1999)
1627
(doi: 10.1039/a902734c)
Dispiroketals in synthesis. Part 24. Preparation and use of chiral 2,2 '-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
1639
(doi: 10.1039/a900950g)
Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
1253
(doi: 10.1039/a901802f)
Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
– J CHEM SOC PERK T 1
(1999)
1251
(doi: 10.1039/a901798d)
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