Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution.
– Journal of Organic Chemistry
(1999)
64,
2737
(doi: 10.1021/jo9821776)
Molybdenum(II)-Catalyzed Allylation of Electron-Rich Aromatics and Heteroaromatics.
– Journal of Organic Chemistry
(1999)
64,
2751
(doi: 10.1021/jo982178y)
1,7-induction of chirality in Mukaiyama aldol reactions using pi-allyltricarbonyliron lactone and lactam complexes as chiral templates
– Tetrahedron
(1999)
55,
3515
Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
375
(doi: 10.1039/a809798d)
Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
107
(doi: 10.1039/a809345h)
Rapid assembly of oligosaccharides:: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
– Angewandte Chemie (International ed. in English)
(1999)
37,
3423
Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives
– Chemtracts
(1999)
12,
27
Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents
– Journal of the Chemical Society - Perkin Transactions 1
(1999)
1253
(doi: 10.1039/a901802f)
Chemistry of insect antifeedants from Azadirachta indica (Part 22): Functionalisation of the decalin fragment of azadirachtin via a Claisen rearrangement reaction
– Synlett
(1999)
1999,
1295
(doi: 10.1055/s-1999-2802)
Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide
– Chemistry - A European Journal
(1999)
5,
3326
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