Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Preparation of desymmetrised meso -tartrate derivatives—synthesis and utility of ( R′ , R′ , R , S )-2,3-butane diacetal protected dimethyl tartrate
DJ Dixon, AC Foster, SV Ley, DJ Reynolds
Journal of the Chemical Society, Perkin Transactions 1
(1999)
(doi: 10.1039/a902733e)
Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
SV Ley, O Schucht, AW Thomas, PJ Murray
Journal of the Chemical Society Perkin Transactions 1
(1999)
(doi: 10.1039/a901798d)
Myocardiac ischemia induced by obstructive sleep apnea in the hypertensive morbidly without known heart disease demonstrated by (SPECT) Te 99m sestamibl preliminary report
A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G García, J Oseguera, O González, J González
HYPERTENSION
(1999)
33
Prevalence of systemic hyprtension in morbid obesity.: Polysomnographic study.
M Fernández, V Rebollar, J Oseguera, A Orea, M Valencia, C Keirns, J Dorantes, M Reséndiz, M Rosales, R Campos, S Ley, X Gómez, J González-B, B García
HYPERTENSION
(1999)
33
Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion
V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González
HYPERTENSION
(1999)
33
Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine
DJ Dixon, SV Ley, T Gracza, P Szolcsanyi
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
(doi: 10.1039/a809823i)
Myocardial ischemia induced by obstructive sleep apnea in the hypertensive morbidly obese without known heart disease demonstrated by (SPECT) Tc 99m sestamibl preliminary report
A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G Garcia, J Oseguera, O González, J González
HYPERTENSION
(1999)
33
Prevalence of systemic hypertension in morbid obesity.: Polysomnographic study.
M Fernández, V Rebollar, J Oseguera, A Orea, M Valencia, C Keirns, J Dorantes, M Reséndiz, M Rosales, R Campos, S Ley, X Gómez, J González-B, G García
HYPERTENSION
(1999)
33
Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in the heart failure (CHF) treatment, effect on coronary microcircula-tion
V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González
HYPERTENSION
(1999)
33
Actions of azadirachtin, a plant allelochemical, against insects
AJ Mordue, MSJ Simmonds, SV Ley, WM Blaney, W Mordue, M Nasiruddin, AJ Nisbet
Pesticide Science
(1999)
54
(doi: 10.1002/(SICI)1096-9063(1998110)54:3<277::AID-PS801>3.0.CO;2-I)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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