Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Use of the potassium ion as a template for the selective derivatization of the antibiotic X-206

AC O'Sulliva, F Struber, SV Ley

Journal of Organic Chemistry

(1999)

6252

(doi: 10.1021/jo9903151)

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex

RW Bates, E Fernández-Megía, SV Ley, K Rück-Braun, DMG Tilbrook

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1917

(doi: 10.1039/a903641e)

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents.

M Caldarelli, J Habermann, SV Ley

Bioorg Med Chem Lett

(1999)

2049

(doi: 10.1016/s0960-894x(99)00311-x)

New building blocks for efficient and highly diastereoselective polyol production—synthesis and utility of (R ′,R ′,S,S ) and (S′,S′,R,R)-2,3-butane diacetal protected butane tetrol derivatives

JS Barlow, DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1627

(doi: 10.1039/a902734c)

Dispiroketals in synthesis.: Part 24.: Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

1639

(doi: 10.1039/a900950g)

Dispiroketals in synthesis.: Part 25.: Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

1647

(doi: 10.1039/a900951e)

A general and efficient procedure for the preparation of enantiopure a/rf/-l,2-diols-synthesis and utility of (Rr ,R',S,K)-2,3-butam diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1635

(doi: 10.1039/a902732g)

Preparation of desymmetrised meso-tartrate derivatives-synthesis and utility of (R,R,R,S)-2,3-butane diacetal protected dimethyl tartrate

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1631

(doi: 10.1039/a902733e)

Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1307

Professor Steve Ley CBE FRS FMedSci

Director of Research

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