Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Preparation of desymmetrised meso-tartrate derivatives -: synthesis and utility of (R′,R′,R,S)-2,3-butane diacetal protected dimethyl tartrate

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1631

(doi: 10.1039/a902733e)

Highly cis- or trans-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers

DJ Dixon, SV Ley, EW Tate

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

2665

(doi: 10.1039/a904891j)

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols—synthesis and utility of (R ′,R ′,S,R)-2,3-butane diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1635

(doi: 10.1039/a902732g)

Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid

DJ Dixon, SV Ley, DA Longbottom

J CHEM SOC PERK T 1

(1999)

2231

(doi: 10.1039/a904921e)

Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents

J Habermann, SV Ley, JJ Scicinski, JS Scott, R Smits, AW Thomas

Journal of the Chemical Society Perkin Transactions 1

(1999)

2425

(doi: 10.1039/a905616e)

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1307

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1999)

1253

(doi: 10.1039/a901802f)

Myocardiac ischemia induced by obstructive sleep apnea in the hypertensive morbidly without known heart disease demonstrated by (SPECT) Te 99m sestamibl preliminary report

A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G García, J Oseguera, O González, J González

HYPERTENSION

(1999)

1303

Synthesis of the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

J Habermann, SV Ley, R Smits

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

2421

(doi: 10.1039/a904384e)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

Research Group

Research Interest Groups

Telephone number

Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge