Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
– Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40,
1043
1,2-Diacetals: A new opportunity for organic synthesis
– Chemical reviews
(2000)
101,
53
(doi: 10.1021/cr990101j)
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
– J CHEM SOC PERK T 1
(2000)
3815
(doi: 10.1039/b006588i)
A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis
– Synlett
(2000)
2000,
1603
(doi: 10.1055/s-2000-7917)
Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
1815
(doi: 10.1039/a909300a)
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
– Organic Syntheses
(2000)
77,
212
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
– Journal of the Chemical Society Perkin Transactions 1
(2000)
3815
(doi: 10.1039/b006588i)
Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S )-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet
– J CHEM SOC PERK T 1
(2000)
2385
(doi: 10.1039/b001243m)
The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahydropyranyl ether derivatives
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
1829
(doi: 10.1039/a909302h)
The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol
– J CHEM SOC PERK T 1
(2000)
3028
(doi: 10.1039/b005942k)
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