Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

J Habermann, SV Ley, R Smits

Journal of the Chemical Society Perkin Transactions 1

(1999)

2421

(doi: 10.1039/a904384e)

pi-allyltricarbonyliron lactone complexes in a diastereoselective Mukaiyama aldol reaction.

SVJ Ley, EA Wright

ABSTR PAP AM CHEM S

(1999)

218

U51

Total synthesis of the plasmoidal pigment physarorubinic acid, a polyenoyl tetramic acid

DJ Dixon, SV Ley, DA Longbottom

Journal of the Chemical Society Perkin Transactions 1

(1999)

2231

(doi: 10.1039/a904921e)

Use of the potassium ion as a template for the selective derivatization of the antibiotic X-206

AC O'Sulliva, F Struber, SV Ley

Journal of Organic Chemistry

(1999)

6252

(doi: 10.1021/jo9903151)

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex

RW Bates, E Fernández-Megía, SV Ley, K Rück-Braun, DMG Tilbrook

Journal of the Chemical Society Perkin Transactions 1

(1999)

1917

(doi: 10.1039/a903641e)

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents.

M Caldarelli, J Habermann, SV Ley

Bioorganic & medicinal chemistry letters

(1999)

2049

(doi: 10.1016/s0960-894x(99)00311-x)

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

1647

(doi: 10.1039/a900951e)

New building blocks for efficient and highly diastereoselective polyol production—synthesis and utility of ( R ′, R ′, S , S ) and ( S ′, S ′, R , R )-2,3-butane diacetal protected butane tetrol derivatives

JS Barlow, DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1627

(doi: 10.1039/a902734c)

Dispiroketals in synthesis. Part 24. Preparation and use of chiral 2,2 '-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

1639

(doi: 10.1039/a900950g)

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols - synthesis and utility of (R ',R ',S,R)-2,3-butane diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

Journal of the Chemical Society Perkin Transactions 1

(1999)

1635

(doi: 10.1039/a902732g)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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