Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
METHYL 2,3-O-(6,6'-OCTAHYDRO-6,6'-BI-2H-PYRAN-2,2'-DIYL)-a-D-GALACTOPYRANOSIDE
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
Deracemization of Baylis-Hillman adducts
Chemtracts
(2000)
13
596
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A convenient hydroxymethyl anion equivalent
Synlett
(2000)
2000
455
(doi: 10.1055/s-2000-6559)
1,2-Diacetals in synthesis: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
Chemistry (Weinheim an der Bergstrasse, Germany)
(1999)
6
172
Synthesis of Glycans from the Glycodelins: Two Undeca-, Two Deca-, Three Nona-, an Octa- and a Heptasaccharide
Chemistry - A European Journal
(1999)
5
3326
Synthesis of Glycans from the Glycodelins: Two Undeca-, Two Deca-, Three Nona-, an Octa- and a Heptasaccharide
Chemistry - A European Journal
(1999)
5
3326
Highly cis- or fraws-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers
Journal of the Chemical Society Perkin Transactions 1
(1999)
2665
(doi: 10.1039/a904891j)
Modified mesoporous silicate MCM-41 materials: Immobilised perruthenate - a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen
Chemical Communications
(1999)
1907
(doi: 10.1039/a906354d)
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