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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, DA Longbottom, M Nesi, JS Scott, RI Storer, SJ Taylor
– J CHEM SOC PERK T 1
(2000)
3815
A rapid approach for the optimisation of polymer supported reagents in synthesis
C Jamieson, MS Congreve, DF Emiabata-Smith, SV Ley
– Synlett
(2000)
2000,
1603
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
SV Ley, HMI Osborn
– Organic Syntheses
(2000)
77,
212
Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S)-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet
DJ Dixon, SV Ley, EW Tate
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
2385
Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives:: an investigation of the reaction mechanism via a double isotopic labelling crossover study
MF Buffet, DJ Dixon, GL Edwards, SV Ley, EW Tate
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
1815
The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives
DJ Dixon, SV Ley, EW Tate
– Journal of the Chemical Society Perkin Transactions 1
(2000)
1829
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, DA Longbottom, M Nesi, JS Scott, RI Storer, SJ Taylor
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
3815
The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol
SV Ley, S Burckhardt
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
3028
1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-substituted beta-hydroxy carbonyl compounds
SV Ley, EA Wright
– J CHEM SOC PERK T 1
(2000)
1677
A short stereoselective total synthesis of the fusarium toxin equisetin
LT Burke, DJ Dixon, SV Ley, F Rodríguez
– Organic Letters
(2000)
2,
3611
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk