Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Rapid assembly of oligosaccharides: 1,2-diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
Tetrahedron Asymmetry
(2000)
11
173
A short and efficient stereoselective synthesis of the polyhydroxylated macrolactone (+)-aspicillin.
Organic Letters
(2000)
2
123
(doi: 10.1021/ol991214s)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes:: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
211
(doi: 10.1039/a907630a)
A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
Deracemization of Baylis-Hillman adducts
Chemtracts
(2000)
13
596
METHYL 2,3-O-(6,6'-OCTAHYDRO-6,6'-BI-2H-PYRAN-2,2'-DIYL)-a-D-GALACTOPYRANOSIDE
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: Generation of a library using orchestrated multistep sequences of polymer-supported reagents and sequesterants
J CHEM SOC PERK T 1
(2000)
3645
(doi: 10.1039/b003129l)
Clean and efficient synthesis of azo dyes using polymer-supported reagents
Green Chemistry
(2000)
2
43
(doi: 10.1039/b000816h)
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A Convenient Hydroxymethyl Anion Equivalent
Synlett
(2000)
2000
455
(doi: 10.1055/s-2000-6559)
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