Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
New polyethylene glycol polymers as ketal protecting groups - A polymer supported approach to symmetrically substituted spiroketals
– Synthetic Communications
(2001)
31,
2965
(doi: 10.1081/SCC-100105668)
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers
– Synlett
(2001)
2001,
1482
(doi: 10.1055/s-2001-16783)
A New Route to Butane-1,2-diacetals and the Development of Alternative Substitution Patterns to Facilitate Differential Protection of the Products
– Synlett
(2001)
2001,
1793
(doi: 10.1055/s-2001-18087)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
– Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40,
1043
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers (Sept, pg 1482, 2001)
– Synlett
(2001)
2004
Solid-phase reaction monitoring--chemical derivatization and off-bead analysis.
– Biotechnol Bioeng
(2001)
71,
110
Characterization of azadirachtin binding to Sf9 nuclei in vitro
– Archives of Insect Biochemistry and Physiology
(2001)
46,
78
(doi: 10.1002/arch.11)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
– Canadian Journal of Chemistry
(2001)
79,
1668
(doi: 10.1139/cjc-79-11-1668)
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