Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing α-1,3-fucosyltransferase V
Bioorg Med Chem
(2000)
8
2519
Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil
Bioorganic & medicinal chemistry letters
(2000)
10
1983
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species
J Comb Chem
(2000)
2
491
(doi: 10.1021/cc000021p)
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferases
Bioorganic and Medicinal Chemistry
(2000)
8
1937
Protecting Groups: Effects on Reactivity, Glycosylation Stereoselectivity, and Coupling Efficiency
(2000)
1-4
427
(doi: 10.1002/9783527618255.ch17)
Synthesis of high-mannose type neoglycolipids: Active targeting of liposomes to macrophages in gene therapy
Chemistry
(2000)
6
1416
Asymmetric molybdenum-catalyzed allylic substitution.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.
ABSTR PAP AM CHEM S
(2000)
219
U132
Polymer Supported Reagents in Synthesis: Preparation of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Combinatorial Decoration
ACS Combinatorial Science
(2000)
2
104
(doi: 10.1021/cc9900697)
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