Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol
J CHEM SOC PERK T 1
(2000)
3028
(doi: 10.1039/b005942k)
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
Organic Syntheses
(2000)
77
212
A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin
Organic letters
(2000)
2
3611
(doi: 10.1021/ol006493u)
The total synthesis of the annonaceous acetogenin, muricatetrocin C
Angewandte Chemie International Edition
(2000)
39
3622
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C We thank the EPSRC (D.J.D. and D.J.R.), the Novartis Research Fellowship (S.V.L.), and the BP Research Endowment (S.V.L.) for generous financial support for this work.
Angew Chem Int Ed Engl
(2000)
39
3622
Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing α-1,3-fucosyltransferase V
Bioorganic & Medicinal Chemistry
(2000)
8
2519
Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil
Bioorganic & Medicinal Chemistry Letters
(2000)
10
1983
Combined application of analytical techniques for the characterization of polymer supported species
Journal of combinatorial chemistry
(2000)
2
491
(doi: 10.1021/cc000021p)
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic Probes for glycosyltransferases
Bioorganic & Medicinal Chemistry
(2000)
8
1937
Protecting groups: Effects on reactivity, glycosylation stereoselectivity, and coupling efficiency
(2000)
1-4
427
(doi: 10.1002/9783527618255.ch17)
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