Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Approaches to the total synthesis of antascomicin A.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221,
U198
Studies toward the total synthesis of rapamycin.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221,
U185
Characterization of azadirachtin binding to Sf9 nuclei in vitro
– Archives of insect biochemistry and physiology
(2001)
46,
78
(doi: 10.1002/arch.11)
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie Curie Fellowship to F.R.), and a Novartis Research Fellowship (to S.V.L.).
– Angewandte Chemie International Edition
(2001)
40,
1053
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging
– Angewandte Chemie International Edition
(2001)
40,
1053
A polymer -supported thionating reagent
– Journal of the Chemical Society. Perkin Transactions 1
(2001)
358
(doi: 10.1039/b008814p)
Synthesis of New Chiral 2,2‘-Bipyridyl-Type Ligands, Their Coordination to Molybdenum(0), Copper(II), and Palladium(II), and Application in Asymmetric Allylic Substitution, Allylic Oxidation, and Cyclopropanation
– Organometallics
(2001)
20,
673
(doi: 10.1021/om000850m)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
– Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
(2001)
40,
1043
Molybdenum( 0 ) and tungsten( 0 ) catalysts with enhanced reactivity for allylic substitution: regioselectivity and solvent effects
– Journal of the Chemical Society. Perkin Transactions 1
(2001)
1234
(doi: 10.1039/b100903f)
New polyethylene glycol polymers as ketal protecting groups - A polymer supported approach to symmetrically substituted spiroketals
– Synthetic Communications
(2001)
31,
2965
(doi: 10.1081/scc-100105668)
- <
- 64 of 105