Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-substituted β-hydroxy carbonyl compounds
Journal of the Chemical Society Perkin Transactions 1
(2000)
1677
(doi: 10.1039/b002056g)
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
Journal of the Chemical Society Perkin Transactions 1
(2000)
3815
(doi: 10.1039/b006588i)
The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives
Journal of the Chemical Society Perkin Transactions 1
(2000)
1829
(doi: 10.1039/a909302h)
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
Organic Syntheses
(2000)
77
212
The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol
Journal of the Chemical Society Perkin Transactions 1
(2000)
3028
(doi: 10.1039/b005942k)
Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: an investigation of the reaction mechanism via a double isotopic labelling crossover study
Journal of the Chemical Society Perkin Transactions 1
(2000)
1815
(doi: 10.1039/a909300a)
A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin
Organic Letters
(2000)
2
3611
(doi: 10.1021/ol006493u)
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Angewandte Chemie International Edition
(2000)
39
3622
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Angew Chem Int Ed Engl
(2000)
39
3622
Membership changes - Reply
CHEMISTRY IN BRITAIN
(2000)
36
23
- ‹ previous
- Page 64
