Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
– Organic Letters
(2001)
3,
3749
(doi: 10.1021/ol016707n)
Tetra-N-propylammonium perruthenate:: a case study in catalyst recovery and re-use involving tetraalkylammonium salts
– Chemical Communications
(2001)
1,
2278
(doi: 10.1039/b107966m)
Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R′,R′,S,R)-2,3-butane diacetal protected butanetetraol derivatives
– Journal of the Chemical Society. Perkin Transactions 1
(2001)
1,
2516
(doi: 10.1039/b105118k)
The Bestmann ylide as a multi-purpose wittig reagent
– Chemtracts
(2001)
14,
386
Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito.
– Molecular and Biochemical Parasitology
(2001)
116,
17
Butane-2,3-diacetal-desymmetrized glycolic acid - A new building block for the stereoselective synthesis of enantiopure α-hydroxy acids
– Angewandte Chemie International Edition
(2001)
40,
2906
Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring
– Journal of Combinatorial Chemistry
(2001)
3,
397
(doi: 10.1021/cc010012w)
Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.
– ACS Combinatorial Science
(2001)
3,
387
(doi: 10.1021/cc0100114)
New catalysts for olefin metathesis
– Chemtracts
(2001)
14,
88
Approaches to the total synthesis of antascomicin A.
– ABSTR PAP AM CHEM S
(2001)
221,
U198
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