Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Solid-Supported Reagents for the Oxidation of Aldehydes to Carboxylic Acids
Synlett
(2001)
2001
1555
(doi: 10.1055/s-2001-17448)
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers
Synlett
(2001)
2001
1482
(doi: 10.1055/s-2001-16783)
Molybdenum(0) and tungsten(0) catalysts with enhanced reactivity for allylic substitution: regioselectivity and solvent effects †
Journal of the Chemical Society, Perkin Transactions 1
(2001)
1234
(doi: 10.1039/b100903f)
The Development and Application of Supported Reagents for Multi-step Organic Synthesis
(2001)
9
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
Canadian Journal of Chemistry
(2001)
79
1668
(doi: 10.1139/cjc-79-11-1668)
Solid-phase reaction monitoring--chemical derivatization and off-bead analysis.
Biotechnology and bioengineering
(2001)
71
110
New polyethylene glycol polymers as ketal protecting groups - A polymer supported approach to symmetrically substituted spiroketals
Synthetic Communications
(2001)
31
2965
(doi: 10.1081/SCC-100105668)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40
1043
1,2-diacetals: a new opportunity for organic synthesis.
Chemical Reviews
(2000)
101
53
(doi: 10.1021/cr990101j)
A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis
Synlett
(2000)
2000
1603
(doi: 10.1055/s-2000-7917)
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