Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Application of polymer-supported enzymes and reagents in the synthesis of γ-aminobutyric acid (GABA) analogues
– Synlett
(2002)
1641
(doi: 10.1055/s-2002-34249)
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
– J. Chem. Soc., Perkin Trans. 1
(2002)
2,
2237
(doi: 10.1039/b207068p)
Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents
– Combinatorial Chemistry and High Throughput Screening
(2002)
5,
197
(doi: 10.2174/1386207024607220)
A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds
– Synlett
(2002)
2002,
516
(doi: 10.1055/s-2002-20483)
Palladium acetate in polyurea microcapsules: A recoverable and reusable catalyst for hydrogenations
– Synlett
(2002)
2002,
1843
(doi: 10.1055/s-2002-34862)
A clean conversion of aldehydes to nitriles using a solid-supported hydrazine
– Synlett
(2002)
2002,
0775
(doi: 10.1055/s-2002-25333)
Analytical techniques for small molecule solid phase synthesis.
– Current Medicinal Chemistry
(2002)
9,
2103
(doi: 10.2174/0929867023368737)
Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative
– Angewandte Chemie - International Edition
(2001)
40,
4763
Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2001)
2,
143
(doi: 10.1039/b109482n)
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
– Org Lett
(2001)
3,
3749
(doi: 10.1021/ol016707n)
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