Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A New Phase‐Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal‐Chelated Tagging
Angewandte Chemie (International ed. in English)
(2001)
40
1053
A polymer -supported thionating reagent
Journal of the Chemical Society Perkin Transactions 1
(2001)
358
(doi: 10.1039/b008814p)
Synthesis of new chiral 2,2 '-bipyridyl-type ligands, their coordination to molybdenum(0), copper(II), and palladium(II), and application in asymmetric allylic substitution, allylic oxidation, and cyclopropanation
Organometallics
(2001)
20
673
(doi: 10.1021/om000850n)
Solid-phase reaction monitoring--chemical derivatization and off-bead analysis.
Biotechnology and bioengineering
(2001)
71
110
The Development and Application of Supported Reagents for Multi-step Organic Synthesis
(2001)
9
Molybdenum( 0 ) and tungsten( 0 ) catalysts with enhanced reactivity for allylic substitution: regioselectivity and solvent effects
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2001)
1234
(doi: 10.1039/b100903f)
A new route to butane-1,2-diacetals and the development of alternative substitution patterns to facilitate differential protection of the products
Synlett
(2001)
2001
1793
(doi: 10.1055/s-2001-18087)
Solid-supported reagents for the oxidation of aldehydes to carboxylic acids
Synlett
(2001)
2001
1555
(doi: 10.1055/s-2001-17448)
A concise synthesis of the natural product carpanone using solid-supported reagents and scavengers
Synlett
(2001)
2001
1482
(doi: 10.1055/s-2001-16783)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40
1043
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