Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Studies toward the total synthesis of rapamycin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221
U185
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging
Angewandte Chemie International Edition
(2001)
40
1053
A polymer -supported thionating reagent
Journal of the Chemical Society Perkin Transactions 1
(2001)
358
(doi: 10.1039/b008814p)
Synthesis of new chiral 2,2′-bipyridyl-type ligands, their coordination to molybdenum(0), copper(II), and palladium(II), and application in asymmetric allylic substitution, allylic oxidation, and cyclopropanation
Organometallics
(2001)
20
673
(doi: 10.1021/om000850n)
The total synthesis of (+)-aspicilin using 2,3-butane diacetal protected butane tetrols via a chiral memory protocol
Canadian Journal of Chemistry
(2001)
79
1668
(doi: 10.1139/cjc-79-11-1668)
Solid-phase reaction monitoring--chemical derivatization and off-bead analysis.
Biotechnol Bioeng
(2001)
71
110
The Development and Application of Supported Reagents for Multi-step Organic Synthesis
(2001)
9
Molybdenum(0) and tungsten(0) catalysts with enhanced reactivity for allylic substitution: Regioselectivity and solvent effects
Journal of the Chemical Society, Perkin Transactions 1
(2001)
1234
(doi: 10.1039/b100903f)
Characterization of azadirachtin binding to Sf9 nuclei in vitro
Archives of Insect Biochemistry and Physiology
(2001)
46
78
(doi: 10.1002/arch.11)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40
1043
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