Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R′,R′,S,R)-2,3-butane diacetal protected butanetetraol derivatives
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2001)
1
2516
(doi: 10.1039/b105118k)
The Bestmann ylide as a multi-purpose wittig reagent
Chemtracts
(2001)
14
386
Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito.
Molecular and biochemical parasitology
(2001)
116
17
Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.
Angewandte Chemie (International ed. in English)
(2001)
40
2906
Looking to the future
CHEMISTRY IN BRITAIN
(2001)
37
24
Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring
Journal of combinatorial chemistry
(2001)
3
397
(doi: 10.1021/cc010012w)
Solid-phase development of a 1-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs
J Comb Chem
(2001)
3
387
(doi: 10.1021/cc0100114)
Data mining and the future of chemistry
MANUFACTURING CHEMIST
(2001)
72
14
New catalysts for olefin metathesis
Chemtracts
(2001)
14
88
Approaches to the total synthesis of antascomicin A.
ABSTR PAP AM CHEM S
(2001)
221
U198
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