Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Alkali Metal Reduction Studies of cis- and trans-Bicyclo[6.1.0]nona-2,4,6-trienes in Liquid Ammonia. Evidence for the High Basicity of Monohomocyclooctatetraene Dianions
– Journal of the American Chemical Society
(2002)
96,
6670
(doi: 10.1021/ja00828a021)
Directed syntheses of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction
– Journal of the American Chemical Society
(2002)
96,
5806
(doi: 10.1021/ja00825a019)
Immobilization of thallium by tandem oxidation/reduction-complexation of thallium(I/III)
– Inorganic Chemistry
(2002)
31,
3963
(doi: 10.1021/ic00045a020)
Formation of Monohomocyclooctatetraene Dianions in Liquid Ammonia. Analysis of the Nucleophilic Reactivity of the Cyclononatrienyl Anions Generated Upon Solvent Protonation
– Journal of the American Chemical Society
(2002)
98,
8162
(doi: 10.1021/ja00441a046)
UNSATURATED HETEROCYCLIC-SYSTEMS .97. THERMAL-ISOMERIZATION OF HOMOAZOCINES
– Journal of the American Chemical Society
(2002)
100,
2909
(doi: 10.1021/ja00477a066)
UNSATURATED HETEROCYCLIC-SYSTEMS .98. SYNTHESIS AND REDUCIBILITY OF HOMO-2-METHOXYAZOCINES AND THEIR BENZO-FUSED DERIVATIVES - EXAMINATION OF HETEROATOMIC INFLUENCES ON POSSIBLE GENERATION OF 9C-10-PI HOMOAROMATIC DIANIONS
– The Journal of Organic Chemistry
(2002)
43,
4712
(doi: 10.1021/jo00419a007)
Luminescence dynamics and carbon-13 NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
– Journal of Physical Chemistry
(2002)
96,
7021
(doi: 10.1021/j100196a033)
Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media
– Chemical communications (Cambridge, England)
(2002)
2,
1134
(doi: 10.1039/b200677b)
Encapsulation of palladium in polyurea microcapsules.
– Chemical communications (Cambridge, England)
(2002)
10,
1132
(doi: 10.1039/b200674j)
Analytical construct resins for analysis of solid-phase chemistry.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8,
- <
- 60 of 105