Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

DJ Dixon, SV Ley, DJ Reynolds

Chemistry (Weinheim an der Bergstrasse, Germany)

(2002)

8

1621

(doi: 10.1002/1521-3765(20020402)8:7<1621::aid-chem1621>3.0.co;2-8)

Analytical construct resins for analysis of solid-phase chemistry.

MS Congreve, SV Ley, JJ Scicinski

Chemistry A European Journal

(2002)

8

1768

(doi: 10.1002/1521-3765(20020415)8:8<1768::aid-chem1768>3.0.co;2-j)

The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids

K Yasuda, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(2002)

2

1024

(doi: 10.1039/b201776h)

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

S Burckhardt, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2002)

2

874

(doi: 10.1039/b201164f)

Total synthesis of the cyclic heptapeptide Argyrin B: A new potent inhibitor of T-cell independent antibody formation

SV Ley, A Priour, C Heusser

Org Lett

(2002)

4

711

(doi: 10.1021/ol017184m)

The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells

A Salehzadeh, A Jabbar, L Jennens, SV Ley, RS Annadurai, R Adams, RHC Strang

Pest Management Science

(2002)

58

268

(doi: 10.1002/ps.449)

Reductive decomplexation of π-allyltricarbonyliron lactone complexes; a new route to stereo-defined 1,7-diols and 2,3-diene-1,7-diols

CJ Hollowood, SV Ley

Chem. Commun.

(2002)

2

2130

(doi: 10.1039/b206406p)

Preface

SV Ley

(2002)

27

vii

(doi: 10.1016/s1572-5995(02)80031-x)

A Polymer-supported Iridium Catalyst for the Stereoselective Isomerisation of Double Bonds

IR Baxendale, A-L Lee, SV Ley

Synlett

(2002)

2002

516

(doi: 10.1055/s-2002-20483)

A Clean Conversion of Aldehydes to Nitriles Using a Solid-Supported Hydrazine

IR Baxendale, SV Ley, HF Sneddon

Synlett

(2002)

2002

0775

(doi: 10.1055/s-2002-25333)