Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The total synthesis of the annonaceous acetogenin, muricatetrocin C.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8
Solid-supported reagents for multi-step organic synthesis: preparation and application
ChemMedChem
(2002)
57
321
The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C
Chemistry A European Journal
(2002)
8
1621
Analytical construct resins for analysis of solid-phase chemistry.
Chemistry A European Journal
(2002)
8
1768
The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2002)
2
1024
(doi: 10.1039/b201776h)
The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol
Journal of the Chemical Society Perkin Transactions 1
(2002)
2
874
(doi: 10.1039/b201164f)
Total synthesis of the cyclic heptapeptide Argyrin B: A new potent inhibitor of T-cell independent antibody formation
Organic letters
(2002)
4
711
(doi: 10.1021/ol017184m)
The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells.
Pest management science
(2002)
58
268
(doi: 10.1002/ps.449)
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
J. Chem. Soc., Perkin Trans. 1
(2002)
2
2237
(doi: 10.1039/b207068p)
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