Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthetic studies toward the total synthesis of Azadirachtin.
– ABSTR PAP AM CHEM S
(2002)
224,
U242
Application of analytical constructs to the development of an indole safety-catch linker family for solid phase organic synthesis.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224,
U175
The synthesis of salmeterol using solid supported reagents.
– ABSTR PAP AM CHEM S
(2002)
224,
U115
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
– Tetrahedron
(2002)
58,
6285
Total synthesis of polycephalin C and determination of the absolute configurations at the 3",4" ring junction
– Angewandte Chemie International Edition
(2002)
41,
2786
New tools and concepts for modern organic synthesis.
– Nature Reviews Drug Discovery
(2002)
1,
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an Ugi reaction
– Bioorg Med Chem Lett
(2002)
12,
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
– J CHEM SOC PERK T 1
(2002)
2,
1850
(doi: 10.1039/b203388g)
Synthesis of taurospongin A:: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
– Chemical communications (Cambridge, England)
(2002)
2,
1624
(doi: 10.1039/b204994p)
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