Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Reductive decomplexation of pi-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
– Org. Biomol. Chem.
(2003)
1,
3197
(doi: 10.1039/b306861g)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
– ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1,
2807
(doi: 10.1039/b305713e)
1,5-Asymmetric induction of chirality using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-functionalised carbonyl compounds
– Org. Biomol. Chem.
(2003)
1,
3208
(doi: 10.1039/b306862e)
Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks
– Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1 ',2 ': 1,5]pyrrolo[2,3-b]indole-1,4-diones
– Org. Biomol. Chem.
(2003)
1,
3492
(doi: 10.1039/b308288a)
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a π-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
– Organic & biomolecular chemistry
(2003)
1,
3263
(doi: 10.1039/b308793j)
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
– Chemtracts
(2003)
16,
443
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A:: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase
– Org. Biomol. Chem.
(2003)
1,
1664
(doi: 10.1039/b301676p)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-ProtectedGlycolic Acid
– Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis
– Organic and Biomolecular Chemistry
(2003)
1,
15
(doi: 10.1039/b208982c)
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