Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of taurospongin A : a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
Chemical communications (Cambridge, England)
(2002)
2
1624
(doi: 10.1039/b204994p)
Total Synthesis of the Amaryllidaceae Alkaloid (+)‐Plicamine and Its Unnatural Enantiomer by Using Solid‐Supported Reagents and Scavengers in a Multistep Sequence of Reactions
Angewandte Chemie International Edition
(2002)
41
2194
Homotropylium-8-sulfinate complexes by antimony pentafluoride-promoted ring opening of 9-thiabicyclo[4.2.1]nona-2,4,7-triene and 9-thiabarbaralane 9,9-dioxides
Journal of the American Chemical Society
(2002)
98
152
(doi: 10.1021/ja00417a023)
Synthesis of Trifluoromethyl Ketones Using Polymer-Supported Reagents
Combinatorial Chemistry & High Throughput Screening
(2002)
5
197
(doi: 10.2174/1386207024607220)
Unsaturated heterocyclic systems. XCII. Nitrogen analogs of 1,6-methano[12]annulene. Effect on valence tautomerism of the locus of aza substitution
The Journal of Organic Chemistry
(2002)
40
902
(doi: 10.1021/jo00895a020)
Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
Journal of Physical Chemistry
(2002)
96
7021
(doi: 10.1021/j100196a033)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions
Journal of Organic Chemistry
(2002)
43
4712
(doi: 10.1021/jo00419a007)
TOTAL SYNTHESIS OF THE IONOPHORE ANTIBIOTIC X-14547A (INDANOMYCIN)
The Journal of Organic Chemistry
(2002)
49
3503
(doi: 10.1021/jo00193a014)
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
The Journal of Organic Chemistry
(2002)
56
5739
(doi: 10.1021/jo00020a002)
Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts
Journal of the American Chemical Society
(2002)
97
4658
(doi: 10.1021/ja00849a031)
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