Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-l,7-diols
– Organic & Biomolecular Chemistry
(2003)
1,
3197
(doi: 10.1039/b306861g)
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase
– Org. Biomol. Chem.
(2003)
1,
1664
(doi: 10.1039/b301676p)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
– Chemical Communications
(2003)
3,
468
(doi: 10.1039/b210673f)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
– Chemical communications (Cambridge, England)
(2003)
678
Synthesis of enantiomers of butane-1,2-diacetal-protected glyceraldehyde and of (R,R)-butane-1,2-diacetal-protected glycolic acid
– Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones
– Organic & biomolecular chemistry
(2003)
1,
3492
(doi: 10.1039/b308288a)
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
– Chemtracts
(2003)
16,
443
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
– ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1,
2807
(doi: 10.1039/b305713e)
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
– Organic & biomolecular chemistry
(2003)
1,
15
(doi: 10.1039/b208982c)
1,5-Asymmetric induction of chirality using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-functionalised carbonyl compounds
– Organic & Biomolecular Chemistry
(2003)
1,
3208
(doi: 10.1039/b306862e)
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