Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of Argyrin B.
ABSTR PAP AM CHEM S
(2002)
224
U242
Application of analytical constructs to the development of an indole safety-catch linker family for solid phase organic synthesis.
ABSTR PAP AM CHEM S
(2002)
224
U175
The synthesis of salmeterol using solid supported reagents.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U115
Synthetic studies toward the total synthesis of Azadirachtin.
ABSTR PAP AM CHEM S
(2002)
224
U242
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
Tetrahedron
(2002)
58
6285
Total synthesis of polycephalin C and determination of the absolute configurations at the 3′′,4′′ ring junction
Angew Chem Int Ed Engl
(2002)
41
2786
Where are the women presidents? - Reply
CHEMISTRY IN BRITAIN
(2002)
38
20
New tools and concepts for modern organic synthesis.
Nature Reviews Drug Discovery
(2002)
1
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an ugi reaction.
Bioorganic & Medicinal Chemistry Letters
(2002)
12
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
Journal of the Chemical Society, Perkin Transactions 1
(2002)
2
1850
(doi: 10.1039/b203388g)
- ‹ previous
- Page 56
