Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of Argyrin B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U242
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
Tetrahedron
(2002)
58
6285
Total synthesis of polycephalin C and determination of the absolute configurations at the 3",4" ring junction
Angew Chem Int Ed Engl
(2002)
41
2786
New tools and concepts for modern organic synthesis.
Nat Rev Drug Discov
(2002)
1
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an Ugi reaction
Bioorganic and Medicinal Chemistry Letters
(2002)
12
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
Journal of the Chemical Society, Perkin Transactions 1
(2002)
2
1850
(doi: 10.1039/b203388g)
Synthesis of taurospongin A : a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
Chem Commun (Camb)
(2002)
2
1624
(doi: 10.1039/b204994p)
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions
Angew Chem Int Ed Engl
(2002)
41
2194
Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
The Journal of Physical Chemistry
(2002)
96
7021
(doi: 10.1021/j100196a033)
Immobilization of Thallium by Tandem Oxidation/Reduction-Complexation of Thallium(I/III)
Inorganic Chemistry
(2002)
31
3963
(doi: 10.1021/ic00045a020)
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