Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Studies toward a total synthesis of bengazole A utilizing BDA-protected building blocks.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U350
Development of new methods suitable for natural product synthesis
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U312
Development of an organic-catalyst mediated cyclopropanation reaction
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U361
Organic-catalyst-mediated cyclopropanation reaction.
– Angewandte Chemie International Edition
(2003)
42,
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
– Chem Commun (Camb)
(2003)
3,
678
(doi: 10.1039/b300074p)
A 2,3-butanedione protected chiral glycine equivalent - a new building block for the stereoselective synthesis of enantiopure N-protected alpha-amino acids
– Chemical communications (Cambridge, England)
(2003)
468
(doi: 10.1039/b210673f)
Development of new synthetic tools for the preparation of biologically active molecules
– CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129,
235
Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV revers transcriptase.
– Organic and Biomolecular Chemistry
(2003)
1,
1664
(doi: 10.1039/b301676p)
Synthesis of enantiomers of butane-1,2-diacetal-protected glyceraldehyde and of (R,R)-butane-1,2-diacetal-protected glycolic acid
– Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: [(2-propenoic acid, 3-iodo-, (2E)-)]
– Organic Syntheses
(2003)
80,
129
(doi: 10.15227/orgsyn.080.0129)
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