Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV reverse transcriptase
Org Biomol Chem
(2003)
1
1664
(doi: 10.1039/b301676p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1
2807
(doi: 10.1039/b305713e)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-l,7-diols
Org. Biomol. Chem.
(2003)
1
3197
(doi: 10.1039/b306861g)
1,5-Asymmetric induction of chirality using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-functionalised carbonyl compounds
Organic and Biomolecular Chemistry
(2003)
1
3208
(doi: 10.1039/b306862e)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-diones.
Organic & Biomolecular Chemistry
(2003)
1
3492
(doi: 10.1039/b308288a)
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a π-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
Organic & Biomolecular Chemistry
(2003)
1
3263
(doi: 10.1039/b308793j)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: [(2-propenoic acid, 3-iodo-, (2E)-)]
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
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