Professor Steve Ley CBE FRS FMedSci | Page 54 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors.

E Vickerstaffe, BH Warrington, M Ladlow, SV Ley

– Organic & Biomolecular Chemistry

(2003)

1,

2419

(doi: 10.1039/b305713e)

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques.

RN MacCoss, PE Brennan, SV Ley

– Organic & Biomolecular Chemistry

(2003)

1,

2029

(doi: 10.1039/b303951j)

A total synthesis of epothilones using solid-supported reagents and scavengers

RI Storer, T Takemoto, PS Jackson, SV Ley

– Angewandte Chemie International Edition

(2003)

42,

2521

(doi: 10.1002/anie.200351413)

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

MS Congreve, C Kay, JJ Scicinski, SV Ley, G Williams, PJ Murray, SC McKeown, SP Watson

– Tetrahedron Letters

(2003)

44,

4153

(doi: 10.1016/S0040-4039(03)00574-4)

Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

HF Sneddon, MJ Gaunt, SV Ley

– Organic Letters

(2003)

5,

1147

(doi: 10.1021/ol034248f)

Synthesis of carbohydrate derivatives using clean chemistry.

RN MacCoss, PE Brennan, SV Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225,

U297

(link to publication)

Development of new methods suitable for natural product synthesis

SV Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225,

U312

(link to publication)

Studies toward the total synthesis of 10-hydroxyasimicin.

SV Ley, DJ Dixon, GL Nattrass, E Diez-Martin

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225,

U349

(link to publication)

Toward a total synthesis of thapsigargin.

SV Ley, SF Oliver, K Hogenauer, O Simic

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225,

U351

(link to publication)

Studies toward a total synthesis of bengazole A utilizing BDA-protected building blocks.

EP Balskus, PE Brennan, SV Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225,

U350

(link to publication)