Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase
Org Biomol Chem
(2003)
1
1664
(doi: 10.1039/b301676p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1
2807
(doi: 10.1039/b305713e)
1,5-asymmetric induction of chirality using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-functionalised carbonyl compounds.
Org Biomol Chem
(2003)
1
3208
(doi: 10.1039/b306862e)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxypyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones
Org. Biomol. Chem.
(2003)
1
3492
(doi: 10.1039/b308288a)
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
Organic & biomolecular chemistry
(2003)
1
3263
(doi: 10.1039/b308793j)
Development of new synthetic tools for the preparation of biologically active molecules
CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129
235
Microencapsulation of osmium tetroxide in polyurea.
Organic Letters
(2002)
5
185
(doi: 10.1021/ol020225+)
Analytical techniques for small molecule solid phase synthesis.
Curr Med Chem
(2002)
9
2103
(doi: 10.2174/0929867023368737)
Benzotriazoles in solid-phase organic chemistry
Chemtracts
(2002)
15
751
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