Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Organic‐Catalyst‐Mediated Cyclopropanation Reaction
Angewandte Chemie International Edition
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: Efficient and chemoselective reduction of aryl ketones
Chem Commun (Camb)
(2003)
3
678
(doi: 10.1039/b300074p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1
2807
(doi: 10.1039/b305713e)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-l,7-diols
Org. Biomol. Chem.
(2003)
1
3197
(doi: 10.1039/b306861g)
1,5-asymmetric induction of chirality using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-functionalised carbonyl compounds.
Org. Biomol. Chem.
(2003)
1
3208
(doi: 10.1039/b306862e)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-diones.
Organic & biomolecular chemistry
(2003)
1
3492
(doi: 10.1039/b308288a)
Synthesis of (-)-gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction.
Org. Biomol. Chem.
(2003)
1
3263
(doi: 10.1039/b308793j)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of ( R , R )-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
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