Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1
– Org Lett
(2003)
5,
4819
(doi: 10.1021/ol035849+)
Modern Synthetic Methods for Copper-Mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S Bond Formation
– Angew Chem Int Ed Engl
(2003)
42,
5400
(doi: 10.1002/anie.200300594)
A practical and efficient synthesis of the C-16-C-28 spiroketal fragment (CD) of the spongistatins.
– Organic letters
(2003)
5,
4815
(doi: 10.1021/ol035848h)
Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides
– Organic letters
(2003)
5,
4665
(doi: 10.1021/ol0358509)
Palladium-containing perovskites: Recoverable and reuseable catalysts for Suzuki couplings
– Chemical communications (Cambridge, England)
(2003)
9,
2652
(doi: 10.1039/b308465e)
A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives.
– Org Lett
(2003)
5,
4553
(doi: 10.1021/ol035567+)
A sequential tetra-n-propylammonium perruthenate (TPAP)-Wittig oxidation olefination protocol
– Tetrahedron Letters
(2003)
44,
7779
(doi: 10.1016/j.tetlet.2003.08.081)
Total synthesis of the polyenoyltetramic acid polycephalin C
– Tetrahedron
(2003)
59,
6955
Synthesis, Chiroptical Properties, and Absolute Configuration of (+)-2,3-Dihydrotriquinacen-2-one. Effect of Rigid Triquinacene Geometry on the Inherently Dissymmetric Chromophore
– Journal of the American Chemical Society
(2003)
97,
7273
(doi: 10.1021/ja00858a600)
Fully automated multi-step solution phase synthesis using polymer supported reagents: Preparation of histone deacetylase inhibitors
– Organic and Biomolecular Chemistry
(2003)
1,
2419
(doi: 10.1039/b305713e)
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