Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of carbohydrate derivatives using clean chemistry.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U297
Organic-catalyst-mediated cyclopropanation reaction.
Angewandte Chemie International Edition
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones
Chem Commun (Camb)
(2003)
3
678
(doi: 10.1039/b300074p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1
2807
(doi: 10.1039/b305713e)
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis.
Organic & biomolecular chemistry
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: A potent inhibitor of DNA polymerase β and HIV reverse transcriptase
Organic and Biomolecular Chemistry
(2003)
1
1664
(doi: 10.1039/b301676p)
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