Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Development of an organocatalytic intramolecular cyclopropanation reaction.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U341
Development of new methods suitable for natural product synthesis
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U312
Development of beta-keto 1,3-dithianes: Versatile platforms for organic synthesis.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U342
Synthesis of carbohydrate derivatives using clean chemistry.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U297
Development of an organic-catalyst mediated cyclopropanation reaction
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U361
Organic-catalyst-mediated cyclopropanation reaction
Angewandte Chemie (International ed. in English)
(2003)
42
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones
Chemical Communications
(2003)
3
678
(doi: 10.1039/b300074p)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of ( R , R )-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Total Synthesis of the PhytotoxicAgent Herbarumin II Using Butane Diacetals of Glycolic Acid as BuildingBlocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis
Organic and Biomolecular Chemistry
(2003)
1
15
(doi: 10.1039/b208982c)
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