Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker

MS Congreve, C Kay, JJ Scicinski, SV Ley, G Williams, PJ Murray, SC McKeown, SP Watson

Tetrahedron Letters

(2003)

44

4153

(doi: 10.1016/s0040-4039(03)00574-4)

Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products

HF Sneddon, MJ Gaunt, SV Ley

Organic Letters

(2003)

5

1147

(doi: 10.1021/ol034248f)

Development of new methods suitable for natural product synthesis

SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U312

Development of an organic-catalyst mediated cyclopropanation reaction

MJ Gaunt, SV Ley, C Papageorgiou, N Bremeyer

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U361

Development of an organocatalytic intramolecular cyclopropanation reaction.

N Bremeyer, MWJ Gaunt, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U341

Development of beta-keto 1,3-dithianes: Versatile platforms for organic synthesis.

HF Sneddon, MJ Gaunt, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U342

Toward a total synthesis of thapsigargin.

SV Ley, SF Oliver, K Hogenauer, O Simic

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U351

Studies toward a total synthesis of bengazole A utilizing BDA-protected building blocks.

EP Balskus, PE Brennan, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U350

Studies toward the total synthesis of 10-hydroxyasimicin.

SV Ley, DJ Dixon, GL Nattrass, E Diez-Martin

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U349

Synthesis of carbohydrate derivatives using clean chemistry.

RN MacCoss, PE Brennan, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2003)

225

U297