Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A Facile One‐Pot Synthesis of a Trisaccharide Unit from the Common Polysaccharide Antigen of Group B Streptococci Using Cyclohexane‐1, 2‐diacetal (CDA) Protected Rhamnosides
– Angewandte Chemie International Edition
(2003)
33,
2292
(doi: 10.1002/anie.199422921)
Cyclohexane‐1,2‐diacetals (CDA): A New Protecting Group for Vicinal Diols in Carbohydrates
– Angewandte Chemie International Edition in English
(2003)
33,
2290
(doi: 10.1002/anie.199422901)
Synthesis of the nonamannan residue of a glycoprotein with high mannose content
– Angewandte Chemie International Edition in English
(2003)
35,
197
(doi: 10.1002/anie.199601971)
Microwave assisted Leimgruber–Batcho reaction for the preparation of indoles , azaindoles and pyrroylquinolines
– Organic & Biomolecular Chemistry
(2003)
2,
160
(doi: 10.1039/b313012f)
A Route to the Thapsigargins from (S)‐Carvone Providing a Substrate‐Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F
– Angewandte Chemie (International ed. in English)
(2003)
42,
5996
(doi: 10.1002/anie.200353140)
Enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine using polymer supported reagents
– Heterocycles
(2003)
60,
2707
(doi: 10.3987/com-03-9892)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: (2-Propenoic acid, 3-iodo-, (2E)-)
– Organic Syntheses
(2003)
80,
129
The Use of Butane Diacetals of Glycolic Acid as Precursors for the Synthesis of the Phytotoxic Calmodulin Inhibitor Herbarumin II
– Helvetica Chimica Acta
(2003)
86,
3717
(doi: 10.1002/hlca.200390314)
The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers
– Org Biomol Chem
(2003)
1,
3957
(doi: 10.1039/b308761a)
Preparation of Butane-1,2-diacetal-protected L-Glyceraldehyde from D-Mannitol
– Synthesis
(2003)
2004,
147
(doi: 10.1055/s-2003-42489)
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