Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A sequential tetra-n-propylammonium perruthenate (TPAP)–Wittig oxidation olefination protocol
Tetrahedron Letters
(2003)
44
7779
(doi: 10.1016/j.tetlet.2003.08.081)
Total synthesis of the polyenoyltetramic acid polycephalin C
Tetrahedron
(2003)
59
6955
Synthesis, Chiroptical Properties, and Absolute Configuration of (+)-2,3-Dihydrotriquinacen-2-one. Effect of Rigid Triquinacene Geometry on the Inherently Dissymmetric Chromophore
Journal of the American Chemical Society
(2003)
97
7273
(doi: 10.1021/ja00858a600)
Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques.
Organic & Biomolecular Chemistry
(2003)
1
2029
(doi: 10.1039/b303951j)
A total synthesis of epothilones using solid-supported reagents and scavengers.
Angew Chem Int Ed Engl
(2003)
42
2521
(doi: 10.1002/anie.200351413)
Versatile solid-phase synthesis of secondary amines from alcohols. Development of an N-Boc-(o-nitrobenzene)sulfonamide linker
Tetrahedron Letters
(2003)
44
4153
Addition of Dithiols to Bis-Ynones: Development of a Versatile Platform for the Synthesis of Polyketide Natural Products
Organic letters
(2003)
5
1147
(doi: 10.1021/ol034248f)
Toward a total synthesis of thapsigargin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U351
Studies toward a total synthesis of bengazole A utilizing BDA-protected building blocks.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U350
Studies toward the total synthesis of 10-hydroxyasimicin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225
U349
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