Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: (2-Propenoic acid, 3-iodo-, (2E)-)
Organic Syntheses
(2003)
80
129
The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II
Helvetica Chimica Acta
(2003)
86
3717
(doi: 10.1002/hlca.200390314)
The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers
Org Biomol Chem
(2003)
1
3957
(doi: 10.1039/b308761a)
Preparation of Butane-1,2-diacetal-protected l -Glyceraldehyde from d -Mannitol
Synthesis
(2003)
2004
147
(doi: 10.1055/s-2003-42489)
Synthesis of the C-1-C-28 ABCD unit of spongistatin 1.
Organic letters
(2003)
5
4819
(doi: 10.1021/ol035849+)
A practical and efficient synthesis of the C-16-C-28 spiroketal fragment (CD) of the spongistatins
Organic letters
(2003)
5
4815
(doi: 10.1021/ol035848h)
Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation
Angewandte Chemie (International ed. in English)
(2003)
42
5400
(doi: 10.1002/anie.200300594)
Recyclable polyurea-microencapsulated Pd(0) nanoparticles: An efficient catalyst for hydrogenolysis of epoxides
Organic letters
(2003)
5
4665
(doi: 10.1021/ol0358509)
Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplingsElectronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b3/b308465e/
Chem Commun (Camb)
(2003)
9
2652
(doi: 10.1039/b308465e)
A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives
Organic letters
(2003)
5
4553
(doi: 10.1021/ol035567+)
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