Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A Practical and Efficient Synthesis of the C-16-C-28 Spiroketal Fragment (CD) of the Spongistatins
Org Lett
(2003)
5
4815
(doi: 10.1021/ol035848h)
Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)-N, and C(aryl)-S bond formation
Angewandte Chemie International Edition
(2003)
42
5400
(doi: 10.1002/anie.200300594)
Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides
Organic Letters
(2003)
5
4665
(doi: 10.1021/ol0358509)
Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings.
Chemical communications (Cambridge, England)
(2003)
9
2652
(doi: 10.1039/b308465e)
A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives.
Organic letters
(2003)
5
4553
(doi: 10.1021/ol035567+)
A sequential tetra-n-propylammonium perruthenate (TPAP)–Wittig oxidation olefination protocol
Tetrahedron Letters
(2003)
44
7779
(doi: 10.1016/j.tetlet.2003.08.081)
Total synthesis of the polyenoyltetramic acid polycephalin C
Tetrahedron
(2003)
59
6955
SYNTHESIS, CHIROPTICAL PROPERTIES, AND ABSOLUTE-CONFIGURATION OF (+)-2,3-DIHYDROTRIQUINACEN-2-ONE - EFFECT OF RIGID TRIQUINACENE GEOMETRY ON INHERENTLY DISSYMMETRIC CHROMOPHORE
Journal of the American Chemical Society
(2003)
97
7273
(doi: 10.1021/ja00858a600)
Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques
Organic & Biomolecular Chemistry
(2003)
1
2029
(doi: 10.1039/b303951j)
A total synthesis of epothilones using solid-supported reagents and scavengers.
Angewandte Chemie (International ed. in English)
(2003)
42
2521
(doi: 10.1002/anie.200351413)
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