Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of the C-1−C-28 ABCD Unit of Spongistatin 1
MJ Gaunt, AS Jessiman, P Orsini, HR Tanner, DF Hook, SV Ley
Org Lett
(2003)
5
(doi: 10.1021/ol035849+)
Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation
SV Ley, AW Thomas
Angewandte Chemie (International ed. in English)
(2003)
42
(doi: 10.1002/anie.200300594)
Recyclable Polyurea-Microencapsulated Pd(0) Nanoparticles: An Efficient Catalyst for Hydrogenolysis of Epoxides
SV Ley, C Mitchell, D Pears, C Ramarao, J-Q Yu, W Zhou
Org Lett
(2003)
5
(doi: 10.1021/ol0358509)
Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings
MD Smith, AF Stepan, C Ramarao, PE Brennan, SV Ley
Chemical Communications
(2003)
9
(doi: 10.1039/b308465e)
A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives
SV Ley, P Michel, C Trapella
Org Lett
(2003)
5
(doi: 10.1021/ol035567+)
A sequential tetra-n-propylammonium perruthenate (TPAP) - Wittig oxidation olefination protocol
RN MacCoss, EP Balskus, SV Ley
Tetrahedron Letters
(2003)
44
(doi: 10.1016/j.tetlet.2003.08.081)
Total synthesis of the polyenoyltetramic acid polycephalin C
DA Longbottom, AJ Morrison, DJ Dixon, SV Ley
Tetrahedron
(2003)
59
(doi: 10.1016/s0040-4020(03)00816-0)
SYNTHESIS, CHIROPTICAL PROPERTIES, AND ABSOLUTE-CONFIGURATION OF (+)-2,3-DIHYDROTRIQUINACEN-2-ONE - EFFECT OF RIGID TRIQUINACENE GEOMETRY ON INHERENTLY DISSYMMETRIC CHROMOPHORE
L Paquette, W Farnham, S Ley
Journal of the American Chemical Society
(2003)
97
(doi: 10.1021/ja00858a600)
Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques.
RN MacCoss, PE Brennan, SV Ley
Organic and Biomolecular Chemistry
(2003)
1
(doi: 10.1039/b303951j)
A total synthesis of epothilones using solid-supported reagents and scavengers
RI Storer, T Takemoto, PS Jackson, SV Ley
Angewandte Chemie International Edition
(2003)
42
(doi: 10.1002/anie.200351413)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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