Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
The first Lewis acid-catalyzed allylboronate additions to aldehydes
– Chemtracts
(2004)
17,
620
Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides
– Angew Chem Int Ed Engl
(2004)
43,
4641
(doi: 10.1002/anie.200460234)
The preparation and alkylation of a butanedione-derived chiral glycine equivalent and its use for the synthesis of α-amino acids and α,α-disubstituted amino acids
– Tetrahedron
(2004)
60,
7679
(doi: 10.1016/j.tet.2004.06.063)
Synthesis of the C-1/C-15 spiroketal fragment (AB) of spongistatin 1.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2004)
228,
U77
A concise total synthesis of (+)-okaramine C
– Organic & Biomolecular Chemistry
(2004)
2,
2415
(doi: 10.1039/b410180d)
5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins.
– Chem Commun (Camb)
(2004)
10,
1808
(doi: 10.1039/b409646k)
Synthesis of the thapsigargins
– Proc Natl Acad Sci U S A
(2004)
101,
12073
(doi: 10.1073/pnas.0403300101)
Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2004)
10,
2529
(doi: 10.1002/chem.200305669)
An intramolecular organocatalytic cyclopropanation reaction
– Angewandte Chemie - International Edition
(2004)
43,
2681
(doi: 10.1002/anie.200454007)
Evolving cascades: The Claisen rearrangement in the development of tandem sequences of three or more reactions
– Chemtracts
(2004)
17,
235
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