Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C

RI Storer, T Takemoto, PS Jackson, DS Brown, IR Baxendale, SV Ley

Chemistry (Weinheim an der Bergstrasse, Germany)

(2004)

10

2529

(doi: 10.1002/chem.200305669)

An Intramolecular Organocatalytic Cyclopropanation Reaction

N Bremeyer, SC Smith, SV Ley, MJ Gaunt

Angewandte Chemie (International ed. in English)

(2004)

43

2681

(doi: 10.1002/anie.200454007)

Evolving cascades: The Claisen rearrangement in the development of tandem sequences of three or more reactions

BL Gray, SV Ley

Chemtracts

(2004)

17

235

Grignard additions to 2-uloses: Synthesis of stereochemically pure tertiary alcohols

E Cleator, CF McCusker, F Steltzer, SV Ley

Tetrahedron Letters

(2004)

45

3077

(doi: 10.1016/j.tetlet.2004.02.106)

Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.

E Vickerstaffe, BH Warrington, M Ladlow, SV Ley

Journal of Combinatorial Chemistry

(2004)

6

332

(doi: 10.1021/cc049977g)

Development of an Indole Safety-Catch Linker Using Analytical Constructs

JJ Scicinski, MS Congreve, SV Ley

Journal of combinatorial chemistry

(2004)

6

375

(doi: 10.1021/cc0499791)

Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (gamma)- and pyranyl (delta)-lactols

MF Buffet, DJ Dixon, SV Ley, DJ Reynolds, RI Storer

Organic & biomolecular chemistry

(2004)

2

1145

(doi: 10.1039/b316858a)

Catalytic polymer-supported potassium thiophenolate in methanol as a method for the removal of ester, amide, and thioacetate protecting groups

SV Ley, RN MacCoss, DJ Henry, CT Brain

Synlett

(2004)

675

(doi: 10.1055/s-2004-817786)

5-Pyrrolidin-2-yltetrazole: A New, Catalytic, More Soluble Alternative to Proline in an Organocatalytic Asymmetric Mannich-type Reaction

AJA Cobb, DM Shaw, SV Ley

Synlett

(2004)

2004

558

(doi: 10.1055/s-2004-817745)

Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors.

A Bapna, E Vickerstaffe, BH Warrington, M Ladlow, T-PD Fan, SV Ley

Organic & biomolecular chemistry

(2004)

2

611

(doi: 10.1039/b313414h)