Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
– Organic Syntheses
(2000)
77,
212
(doi: 10.15227/orgsyn.077.0212)
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane:: A convenient hydroxymethyl anion equivalent
– Synlett
(2000)
2000,
455
(doi: 10.1055/s-2000-6559)
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor CMI-977
– Synthetic Communications
(2000)
30,
1955
(doi: 10.1080/00397910008087245)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
– Chemtracts
(2000)
13,
66
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants
– Journal of the Chemical Society Perkin Transactions 1
(2000)
3645
(doi: 10.1039/b003129l)
1,2-diacetals in synthesis:: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
– Chemistry
(1999)
6,
172
Synthesis of Glycans from the Glycodelins: Two Undeca‐, Two Deca‐, Three Nona‐, an Octa‐ and a Heptasaccharide
– Chemistry A European Journal
(1999)
5,
3326
Highly cis- or trans-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers
– Journal of the Chemical Society, Perkin Transactions 1
(1999)
2665
(doi: 10.1039/a904891j)
Modified mesoporous silicate MCM-41 materials: immobilised perruthenate - a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen
– Chemical Communications
(1999)
1907
(doi: 10.1039/a906354d)
- <
- 70 of 108