Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations

S Ley, D Browne, M O'Brien, P Koos, P Cranwell, A Polyzos

Synlett

(2012)

1402

(doi: 10.1055/s-0031-1290963)

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

C Battilocchio, IR Baxendale, M Biava, MO Kitching, SV Ley

Organic Process Research & Development

(2012)

798

(doi: 10.1021/op300084z)

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.

PB Cranwell, M O'Brien, DL Browne, P Koos, A Polyzos, M Peña-López, SV Ley

Organic and Biomolecular Chemistry

(2012)

5774

(doi: 10.1039/c2ob25407g)

Discovery, design and synthesis of a novel series of non-peptidomimetic inhibitors of XIAP-caspase 9 interactions

DM Allwood, RM Myers, F Richards, A Bender, C Watts, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2012)

243

The Lab of the Future. the importance of remote monitoring and control

MD Hopkin, IR Baxendale, SV Ley

Chimica Oggi Chemistry Today

(2012)

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1

TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers

Bioorganic and Medicinal Chemistry

(2012)

1749

(doi: 10.1016/j.bmc.2012.01.010)

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.

BCS Cross, PJ Bond, PG Sadowski, BK Jha, J Zak, JM Goodman, RH Silverman, TA Neubert, IR Baxendale, D Ron, HP Harding

Proc Natl Acad Sci U S A

(2012)

109

e869

(doi: 10.1073/pnas.1115623109)

Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands

C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin

Synthesis

(2012)

635

(doi: 10.1055/s-0031-1289676)

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles

TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian

ACS Medicinal Chemistry Letters

(2012)

177

(doi: 10.1021/ml200149g)

A total synthesis of millingtonine a

J Wegner, SV Ley, A Kirschning, A-L Hansen, JM Garcia, IR Baxendale

Organic Letters

(2012)

696

(doi: 10.1021/ol203158p)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

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