Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A total synthesis of the ammonium ionophore, (−)-enniatin B
– Tetrahedron Letters
(2012)
53,
4077
(doi: 10.1016/j.tetlet.2012.05.110)
A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the imatinib base
– Org Lett
(2012)
14,
3920
(doi: 10.1021/ol301673q)
Continuous flow reaction monitoring using an on-line miniature mass spectrometer
– Rapid Communications in Mass Spectrometry
(2012)
26,
1999
(doi: 10.1002/rcm.6312)
Establishing a Flow Process to Coumarin‐8‐Carbaldehydes as Important Synthetic Scaffolds
– Chemistry A European Journal
(2012)
18,
9901
(doi: 10.1002/chem.201201039)
On being green: can flow chemistry help?
– Chemical Record
(2012)
12,
378
(doi: 10.1002/tcr.201100041)
Asymmetric Homogeneous Hydrogenation in Flow using a Tube‐in‐Tube Reactor
– Advanced Synthesis & Catalysis
(2012)
354,
1805
(doi: 10.1002/adsc.201200073)
Rotamers or diastereomers? An overlooked NMR solution
– J Org Chem
(2012)
77,
5198
(doi: 10.1021/jo300734r)
Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations
– Synlett
(2012)
23,
1402
(doi: 10.1055/s-0031-1290963)
A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid
– Organic Process Research and Development
(2012)
16,
798
(doi: 10.1021/op300084z)
Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.
– Organic & Biomolecular Chemistry
(2012)
10,
5774
(doi: 10.1039/c2ob25407g)
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