Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Twenty five years of azadirachtins

HE Hummel, DF Hein, W Kraus, SV Ley, ED Morgan, H Schmutterer

MITTEILUNGEN DER DEUTSCHEN GESELLSCHAFT FUR ALLGEMEINE UND ANGEWANDTE ENTOMOLOGIE, BD 18

(2012)

18

467

Piecing together the puzzle: Understanding a mild, metal free reduction method for the large scale synthesis of hydrazines

DL Browne, IR Baxendale, SV Ley

Tetrahedron

(2011)

67

10296

(doi: 10.1016/j.tet.2011.09.146)

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley

Beilstein J Org Chem

(2011)

7

1648

(doi: 10.3762/bjoc.7.194)

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

T Brodmann, P Koos, A Metzger, P Knochel, SV Ley

Organic Process Research and Development

(2011)

16

1102

(doi: 10.1021/op200275d)

The continuous-flow synthesis of styrenes using ethylene in a palladium-catalysed heck cross-coupling reaction

S Ley, S Bourne, P Koos, M O’Brien, B Martin, B Schenkel, I Baxendale

Synlett

(2011)

2011

2643

(doi: 10.1055/s-0031-1289291)

Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

S Ley, S Kasinathan, S Bourne, P Tolstoy, P Koos, M O’Brien, R Bates, I Baxendale

Synlett

(2011)

2011

2648

(doi: 10.1055/s-0031-1289292)

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

TP Petersen, A Polyzos, M O'Brien, T Ulven, IR Baxendale, SV Ley

Chemsuschem

(2011)

5

274

(doi: 10.1002/cssc.201100339)

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

P Koos, U Gross, A Polyzos, M O'Brien, I Baxendale, SV Ley

Organic & Biomolecular Chemistry

(2011)

9

6903

(doi: 10.1039/c1ob06017a)

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

M Baumann, IR Baxendale, SV Ley

Molecular Diversity

(2011)

15

613

(doi: 10.1007/s11030-010-9282-1)

Practical Synthetic Organic Chemistry

SV Ley

Practical Synthetic Organic Chemistry Reactions Principles and Techniques

(2011)

vii

(doi: 10.1002/9781118093559)