Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring

T Brodmann, P Koos, A Metzger, P Knochel, SV Ley

Organic Process Research & Development

(2011)

16

1102

(doi: 10.1021/op200275d)

The continuous-flow synthesis of styrenes using ethylene in a palladium-catalysed heck cross-coupling reaction

S Ley, S Bourne, P Koos, M O’Brien, B Martin, B Schenkel, I Baxendale

Synlett

(2011)

2011

2643

(doi: 10.1055/s-0031-1289291)

Syngas-mediated C-C bond formation in flow: Selective rhodium-catalysed hydroformylation of styrenes

S Ley, S Kasinathan, S Bourne, P Tolstoy, P Koos, M O’Brien, R Bates, I Baxendale

Synlett

(2011)

2011

2648

(doi: 10.1055/s-0031-1289292)

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

TP Petersen, A Polyzos, M O'Brien, T Ulven, IR Baxendale, SV Ley

ChemSusChem

(2011)

5

274

(doi: 10.1002/cssc.201100339)

Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

P Koos, U Gross, A Polyzos, M O'Brien, I Baxendale, SV Ley

Org Biomol Chem

(2011)

9

6903

(doi: 10.1039/c1ob06017a)

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

M Baumann, IR Baxendale, SV Ley

Molecular Diversity

(2011)

15

613

(doi: 10.1007/s11030-010-9282-1)

Foreword

SV Ley

Practical Synthetic Organic Chemistry Reactions Principles and Techniques

(2011)

vii

(doi: 10.1002/9781118093559)

Piperazic acid -containing natural products : Isolation, biological relevance and total synthesis

AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley

Natural Product Reports

(2011)

28

1445

(doi: 10.1039/c1np00041a)

Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure

M O'Brien, N Taylor, A Polyzos, IR Baxendale, SV Ley

Chemical Science

(2011)

2

1250

(doi: 10.1039/c1sc00055a)

A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures

DL Browne, M Baumann, BH Harji, IR Baxendale, SV Ley

Organic letters

(2011)

13

3312

(doi: 10.1021/ol2010006)