Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The clerodane ring system: Investigating the viability of a direct Diels-Alder approach
Organic and Biomolecular Chemistry
(2011)
9
4745
(doi: 10.1039/c1ob05422h)
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
ACS Comb Sci
(2011)
13
405
(doi: 10.1021/co2000357)
Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme
Proc Natl Acad Sci U S A
(2011)
108
8698
(doi: 10.1073/pnas.1103802108)
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
Chemical Science
(2011)
2
765
(doi: 10.1039/c0sc00603c)
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.
Beilstein journal of organic chemistry
(2011)
7
442
(doi: 10.3762/bjoc.7.57)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae
Entomologia Experimentalis Et Applicata
(2011)
55
149
Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues
Entomologia Experimentalis et Applicata
(2011)
77
69
Insect antifeedants: a behavioural and electrophysiological investigation of natural and synthetically derived clerodane diterpenoids
Entomologia Experimentalis et Applicata
(2011)
46
267
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae
Entomologia Experimentalis et Applicata
(2011)
55
169
Lesser-known enabling technologies for organic synthesis
Synthesis
(2011)
1157
(doi: 10.1055/s-0030-1259979)
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