Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Piperazic acid -containing natural products : Isolation, biological relevance and total synthesis
Natural Product Reports
(2011)
28
1445
(doi: 10.1039/c1np00041a)
Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure
Chemical Science
(2011)
2
1250
(doi: 10.1039/c1sc00055a)
A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures
Org Lett
(2011)
13
3312
(doi: 10.1021/ol2010006)
The clerodane ring system: investigating the viability of a direct Diels–Alder approach
Organic and Biomolecular Chemistry
(2011)
9
4745
(doi: 10.1039/c1ob05422h)
Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods
ACS Combinatorial Science
(2011)
13
405
(doi: 10.1021/co2000357)
Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme
Proceedings of the National Academy of Sciences
(2011)
108
8698
(doi: 10.1073/pnas.1103802108)
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
Chemical Science
(2011)
2
765
(doi: 10.1039/c0sc00603c)
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals
Beilstein J Org Chem
(2011)
7
442
(doi: 10.3762/bjoc.7.57)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae
Entomologia Experimentalis Et Applicata
(2011)
55
149
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae
Entomologia Experimentalis Et Applicata
(2011)
55
169
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