Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae

MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, PL Toogood

Entomologia Experimentalis Et Applicata

(2011)

169

(doi: 10.1111/j.1570-7458.1990.tb01360.x)

Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae

WM Blaney, MSJ Simmonds, SV Ley, JC Anderson, PL Toogood

Entomologia Experimentalis Et Applicata

(2011)

149

(doi: 10.1111/j.1570-7458.1990.tb01358.x)

Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues

MSJ Simmonds, WM Blaney, SV Ley, JC Anderson, R Banteli, AA Denholm, PCW Green, RB Grossman, C Gutteridge, L Jennens, SC Smith, PL Toogood, A Wood

Entomologia Experimentalis et Applicata

(2011)

(doi: 10.1111/j.1570-7458.1995.tb01987.x)

Lesser-known enabling technologies for organic synthesis

M O'Brien, R Denton, SV Ley

Synthesis

(2011)

1157

(doi: 10.1055/s-0030-1259979)

In-line monitoring for the accurate control of segmented flow processes

CF Carter, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2011)

241

Oxidation reactions in segmented and continuous flow chemical processing using an N -(tert -Butyl)phenylsulfinimidoyl chloride monolith

H Lange, MJ Capener, AX Jones, CJ Smith, N Nikbin, IR Baxendale, SV Ley

Synlett

(2011)

869

(doi: 10.1055/s-0030-1259923)

Total Synthesis of Chloptosin: A Dimeric Cyclohexapeptide

AJ Oelke, F Antonietti, L Bertone, PB Cranwell, DJ France, RJM Goss, T Hofmann, S Knauer, SJ Moss, PC Skelton, RM Turner, G Wuitschik, SV Ley

Chemistry - A European Journal

(2011)

4183

(doi: 10.1002/chem.201003216)

Continuous flow processing of slurries: Evaluation of an agitated cell reactor

DL Browne, BJ Deadman, R Ashe, IR Baxendale, SV Ley

Organic Process Research & Development

(2011)

693

(doi: 10.1021/op2000223)

Synthesis of highly substituted nitropyrrolidines, nitropyrrolizines and nitropyrroles via multicomponent-multistep sequences within a flow reactor

S V. Ley, M Baumann, I R. Baxendale, A Kirschning, J Wegner

Heterocycles

(2011)

1297

(doi: 10.3987/com-10-s(e)77)

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

CF Carter, H Lange, D Sakai, IR Baxendale, SV Ley

Chemistry - A European Journal

(2011)

3398

(doi: 10.1002/chem.201003148)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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