Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.
Organic & biomolecular chemistry
(2011)
9
1927
(doi: 10.1039/c0ob00813c)
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Organic & Biomolecular Chemistry
(2011)
9
1938
(doi: 10.1039/c0ob00815j)
An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole
Synlett
(2011)
1375
(doi: 10.1055/s-0030-1260573)
New Synthetic Technologies in Medicinal Chemistry Foreword
(2011)
11
V
(doi: 10.1039/9781849733052-FP005)
The lab of the future: The importance of remote monitoring and control
Chimica Oggi
(2011)
29
28
The Continuous‐Flow Synthesis of Carboxylic Acids using CO2 in a Tube‐In‐Tube Gas Permeable Membrane Reactor
Angewandte Chemie
(2010)
123
1222
(doi: 10.1002/ange.201006618)
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
Org Lett
(2010)
13
320
(doi: 10.1021/ol1027927)
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