Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
The Journal of biological chemistry
(2011)
286
16163
(doi: 10.1074/jbc.m110.171082)
The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.
Angewandte Chemie International Edition
(2011)
50
1190
(doi: 10.1002/anie.201006618)
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
Organic & Biomolecular Chemistry
(2011)
9
1927
(doi: 10.1039/c0ob00813c)
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Org Biomol Chem
(2011)
9
1938
(doi: 10.1039/c0ob00815j)
New Synthetic Technologies in Medicinal Chemistry Foreword
(2011)
11
V
(doi: 10.1039/9781849733052-FP005)
An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole
Synlett
(2011)
1375
(doi: 10.1055/s-0030-1260573)
The lab of the future: The importance of remote monitoring and control
Chimica Oggi
(2011)
29
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