Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Microwave and flow syntheses of Pseudomonasquinolone signal (PQS) and analogues
Org Biomol Chem
(2010)
9
57
(doi: 10.1039/c0ob00652a)
Total syntheses of subereamollines A and B
Organic and Biomolecular Chemistry
(2010)
9
62
(doi: 10.1039/c0ob00636j)
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.
Organic & Biomolecular Chemistry
(2010)
8
5324
(doi: 10.1039/c0ob00450b)
A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist.
Chemistry A European Journal
(2010)
16
12342
(doi: 10.1002/chem.201002147)
Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44
Tetrahedron Letters
(2010)
51
4812
(doi: 10.1016/j.tetlet.2010.07.016)
DISPIROKETALS IN SYNTHESIS .16. FUNCTIONALIZED DISPIROKETALS AS NEW CHIRAL AUXILIARIES - THE SYNTHESIS OF DIHYDROXYLATED DISPIROKETALS IN OPTICALLY PURE FORM AND THEIR APPLICATION AS BIFUNCTIONAL, C-2-SYMMETRICAL, CHIRAL AUXILIARIES FOR HIGHLY STEREOSELECTIVE MICHAEL ADDITIONS
Recueil Des Travaux Chimiques Des Paysbas
(2010)
114
184
(doi: 10.1002/recl.19951140410)
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
Medchemcomm
(2010)
1
202
(doi: 10.1039/c0md00095g)
New Routes to Biologically Active Heterocyclic Natural Products
Bulletin des Sociétés Chimiques Belges
(2010)
101
641
(doi: 10.1002/bscb.19921010711)
Flow chemistry for natural product synthesis: Towards the syntheses of spiragiens A and B
ABSTR PAP AM CHEM S
(2010)
240
Towards the total synthesis of leustroducsin B
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2010)
240
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