Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2010)
17
329
(doi: 10.1002/chem.201002380)
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proceedings of the National Academy of Sciences
(2010)
107
20483
(doi: 10.1073/pnas.1008255107)
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues
Org. Biomol. Chem.
(2010)
9
57
(doi: 10.1039/c0ob00652a)
Total syntheses of subereamollines A and B.
Organic and Biomolecular Chemistry
(2010)
9
62
(doi: 10.1039/c0ob00636j)
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor
Org Biomol Chem
(2010)
8
5324
(doi: 10.1039/c0ob00450b)
A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4- ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist
Chemistry A European Journal
(2010)
16
12342
(doi: 10.1002/chem.201002147)
Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44
Tetrahedron Letters
(2010)
51
4812
(doi: 10.1016/j.tetlet.2010.07.016)
Dispiroketals in synthesis (Part 16): Functionalised dispiroketals as new chiral auxiliaries; the synthesis of dihydroxylated dispiroketals in optically pure form and their application as bifunctional, C2‐symmetrical, chiral auxiliaries for highly stereoselective Michael additions
Recueil des Travaux Chimiques des Pays-Bas
(2010)
114
184
(doi: 10.1002/recl.19951140410)
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
MedChemComm
(2010)
1
202
(doi: 10.1039/c0md00095g)
New Routes to Biologically Active Heterocyclic Natural Products
Bulletin Des Societes Chimiques Belges
(2010)
101
641
(doi: 10.1002/bscb.19921010711)
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