Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total Synthesis of Chloptosin
Angewandte Chemie International Edition
(2010)
49
6139
(doi: 10.1002/anie.201002880)
KMnO4-Mediated Oxidation as a Continuous Flow Process
Organic Letters
(2010)
12
3618
(doi: 10.1021/ol101345z)
A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation
Advanced Synthesis & Catalysis
(2010)
352
1736
(doi: 10.1002/adsc.201000139)
Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes
Synlett
(2010)
2010
1919
(doi: 10.1055/s-0030-1258486)
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
Organic and Biomolecular Chemistry
(2010)
8
1798
(doi: 10.1039/b925327k)
Multiple Microcapillary Reactor for Organic Synthesis
Industrial & Engineering Chemistry Research
(2010)
49
4576
(doi: 10.1021/ie901674h)
Novel palindromic ligands cementing the native quaternary structure of transthyretin
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17
49
Targeting transthyretin - X-ray crystallography and rational drug design
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17
102
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact
Organic letters
(2010)
12
1596
(doi: 10.1021/ol100322t)
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