Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
RSC Medicinal Chemistry
(2010)
1
202
(doi: 10.1039/c0md00095g)
New Routes to Biologically Active Heterocyclic Natural Products
Bulletin des Sociétés Chimiques Belges
(2010)
101
641
(doi: 10.1002/bscb.19921010711)
Award Address (Tetrahedron Prize for Creativity in Organic Chemistry, sponsored by Elsevier). Changing face of organic synthesis
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2010)
240
Flow chemistry for natural product synthesis: Towards the syntheses of spiragiens A and B
ABSTR PAP AM CHEM S
(2010)
240
Towards the total synthesis of leustroducsin B
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2010)
240
Total synthesis of chloptosin.
Angewandte Chemie (International ed. in English)
(2010)
49
6139
(doi: 10.1002/anie.201002880)
KMnO(4)-Mediated oxidation as a continuous flow process.
Org Lett
(2010)
12
3618
(doi: 10.1021/ol101345z)
A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation
Advanced Synthesis & Catalysis
(2010)
352
1736
(doi: 10.1002/adsc.201000139)
Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes
Synlett
(2010)
2010
1919
(doi: 10.1055/s-0030-1258486)
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