Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole
– Synlett
(2011)
1375
(doi: 10.1055/s-0030-1260573)
New Synthetic Technologies in Medicinal Chemistry Foreword
(2011)
11,
V
(doi: 10.1039/9781849733052-FP005)
The Continuous‐Flow Synthesis of Carboxylic Acids using CO2 in a Tube‐In‐Tube Gas Permeable Membrane Reactor
– Angewandte Chemie
(2010)
123,
1222
(doi: 10.1002/ange.201006618)
The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor
– Angew Chem Int Ed Engl
(2010)
50,
1190
(doi: 10.1002/anie.201006618)
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
– Org Lett
(2010)
13,
320
(doi: 10.1021/ol1027927)
Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.
– Chemistry
(2010)
17,
329
(doi: 10.1002/chem.201002380)
Total Synthesis of Iso- and Bongkrekic Acids: Natural Antibiotics Displaying Potent Antiapoptotic Properties
– Chemistry - A European Journal
(2010)
17,
329
(doi: 10.1002/chem.201002380)
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
– Proceedings of the National Academy of Sciences
(2010)
107,
20483
(doi: 10.1073/pnas.1008255107)
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues
– Organic & biomolecular chemistry
(2010)
9,
57
(doi: 10.1039/c0ob00652a)
The flow synthesis of heterocycles for natural product and medicinal chemistry applications.
– Molecular diversity
(2010)
15,
1
(doi: 10.1007/s11030-010-9282-1)
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