Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The application of flow microreactors to the preparation of a family of casein kinase i inhibitors

F Venturoni, N Nikbin, SV Ley, IR Baxendale

Org Biomol Chem

(2010)

1798

(doi: 10.1039/b925327k)

Multiple Microcapillary Reactor for Organic Synthesis

CH Hornung, B Hallmark, M Baumann, IR Baxendale, SV Ley, P Hester, P Clayton, MR Mackley

Industrial & Engineering Chemistry Research

(2010)

4576

(doi: 10.1021/ie901674h)

Novel palindromic ligands cementing the native quaternary structure of transthyretin

PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(2010)

Targeting transthyretin - X-ray crystallography and rational drug design

S Kolstoe, AJ Morrison, AJA Cobb, A Coyne, R Gill, MD Smith, SV Ley, SP Wood, MB Pepys

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(2010)

102

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact

M O'Brien, IR Baxendale, SV Ley

Organic Letters

(2010)

1596