Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Novel palindromic ligands cementing the native quaternary structure of transthyretin

PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(2010)

17

49

Targeting transthyretin - X-ray crystallography and rational drug design

S Kolstoe, AJ Morrison, AJA Cobb, A Coyne, R Gill, MD Smith, SV Ley, SP Wood, MB Pepys

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

(2010)

17

102

Green Chemistry in the Pharmaceutical Industry

G Whittington

(2010)

xi

(doi: 10.1002/9783527629688)

Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas-liquid contact.

M O'Brien, IR Baxendale, SV Ley

Org Lett

(2010)

12

1596

(doi: 10.1021/ol100322t)

A flow-based synthesis of Imatinib : the API of Gleevec

MD Hopkin, IR Baxendale, SV Ley

Chemical Communications

(2010)

46

2450

(doi: 10.1039/c001550d)

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors

CF Carter, IR Baxendale, JBJ Pavey, SV Ley

Organic & Biomolecular Chemistry

(2010)

8

1588

(doi: 10.1039/b924309g)

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT(1B) Antagonist

S Ley, Z Qian, I Baxendale

Synlett

(2010)

2010

505

(doi: 10.1055/s-0029-1219358)

ReactIR flow cell: A new analytical tool for continuous flow chemical processing

CF Carter, H Lange, SV Ley, IR Baxendale, B Wittkamp, JG Goode, NL Gaunt

Organic Process Research & Development

(2010)

14

393

(doi: 10.1021/op900305v)

Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor

S Ley, M Baumann, I Baxendale

Synlett

(2010)

2010

749

(doi: 10.1055/s-0029-1219344)

Multi-Step synthesis by using modular flow reactors: The preparation of Yne-Ones and their use in heterocycle synthesis

IR Baxendale, SC Schou, J Sedelmeier, SV Ley

Chemistry – A European Journal

(2009)

16

89

(doi: 10.1002/chem.200902906)