Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
Org Biomol Chem
(2009)
7
4594
(doi: 10.1039/b917289k)
Total synthesis of (-)-spirangien a and the corresponding methyl ester
Chemtracts
(2009)
22
173
Pd‐EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl‐ and Alkenyl‐Substituted Acetylenes via Microwave‐Assisted Sonogashira Type Reactions
European Journal of Organic Chemistry
(2009)
2009
4412
(doi: 10.1002/ejoc.200900344)
Development of fluorination methods using continuous-flow microreactors
Tetrahedron
(2009)
65
6611
(doi: 10.1016/j.tet.2009.05.083)
Enantioselective synthesis of the lyngbouilloside macrolactone core
Synlett
(2009)
2009
2320
(doi: 10.1055/s-0029-1217707)
A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Tetrahedron Letters
(2009)
50
3287
(doi: 10.1016/j.tetlet.2009.02.059)
CHEMICAL SAFETY Mg3N2 EXPLOSION RISK
CHEMICAL & ENGINEERING NEWS
(2009)
87
4
Cancer, chemistry, and the cell: Molecules that interact with the neurotensin receptors
ACS chemical biology
(2009)
4
503
(doi: 10.1021/cb900038e)
Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.
Beilstein J Org Chem
(2009)
5
23
(doi: 10.3762/bjoc.5.23)
Copper-Catalyzed Arylations of Amines and Alcohols with Boron-Based Arylating Reagents
MODERN ARYLATION METHODS
(2009)
121
(doi: 10.1002/9783527627325.ch4)
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