Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
'The changing face of organic synthesis'
– Tetrahedron
(2010)
66,
6270
(doi: 10.1016/j.tet.2010.05.049)
Total synthesis of chloptosin
– Angew Chem Int Ed Engl
(2010)
49,
6139
(doi: 10.1002/anie.201002880)
KMnO4-Mediated Oxidation as a Continuous Flow Process
– Organic Letters
(2010)
12,
3618
(doi: 10.1021/ol101345z)
A palladium wall coated microcapillary reactor for use in continuous flow transfer hydrogenation
– Advanced Synthesis and Catalysis
(2010)
352,
1736
(doi: 10.1002/adsc.201000139)
Enzymatic oxidative cyclisation reactions leading to dibenzoazocanes
– Synlett
(2010)
2010,
1919
(doi: 10.1055/s-0030-1258486)
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
– Organic and Biomolecular Chemistry
(2010)
8,
1798
(doi: 10.1039/b925327k)
Multiple microcapillary reactor for organic synthesis
– Industrial & Engineering Chemistry Research
(2010)
49,
4576
(doi: 10.1021/ie901674h)
Targeting transthyretin - X-ray crystallography and rational drug design
– AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17,
102
Novel palindromic ligands cementing the native quaternary structure of transthyretin
– AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2010)
17,
49
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