Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A total synthesis of the ammonium ionophore, (-)-enniatin B

DX Hu, M Bielitza, P Koos, SV Ley

Tetrahedron Letters

(2012)

53

4077

(doi: 10.1016/j.tetlet.2012.05.110)

Continuous Multiple Liquid-Liquid Separation: Diazotization of Amino Acids in Flow

DX Hu, M O'Brien, SV Ley

Org Lett

(2012)

14

4246

(doi: 10.1021/ol301930h)

A prototype continuous-flow liquid–liquid extraction system using open-source technology

M O'Brien, P Koos, DL Browne, SV Ley

Organic & Biomolecular Chemistry

(2012)

10

7031

(doi: 10.1039/c2ob25912e)

On being green: Can flow chemistry help?

SV Ley

Chemical Record

(2012)

12

378

(doi: 10.1002/tcr.201100041)

A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the imatinib base

RJ Ingham, E Riva, N Nikbin, IR Baxendale, SV Ley

Org Lett

(2012)

14

3920

(doi: 10.1021/ol301673q)

Continuous flow reaction monitoring using an on‐line miniature mass spectrometer

DL Browne, S Wright, BJ Deadman, S Dunnage, IR Baxendale, RM Turner, SV Ley

Rapid Commun Mass Spectrom

(2012)

26

1999

(doi: 10.1002/rcm.6312)

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds

J Zak, D Ron, E Riva, HP Harding, BCS Cross, IR Baxendale

Chemistry

(2012)

18

9901

(doi: 10.1002/chem.201201039)

Asymmetric homogeneous hydrogenation in flow using a tube-in-tube reactor

S Newton, SV Ley, EC Arcé, DM Grainger

Advanced Synthesis & Catalysis

(2012)

354

1805

(doi: 10.1002/adsc.201200073)

Rotamers or diastereomers? An overlooked NMR solution.

DX Hu, P Grice, SV Ley

Journal of Organic Chemistry

(2012)

77

5198

(doi: 10.1021/jo300734r)

Continuous-flow processing of gaseous ammonia using a Teflon AF-2400 tube-in-tube reactor: Synthesis of thioureas and in-line titrations

S Ley, D Browne, M O'Brien, P Koos, P Cranwell, A Polyzos

Synlett

(2012)

23

1402

(doi: 10.1055/s-0031-1290963)