Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Convergent total syntheses of callipeltosides A, B, and C

JR Frost, CM Pearson, TN Snaddon, RA Booth, SV Ley

Angewandte Chemie International Edition

(2012)

51

9366

(doi: 10.1002/anie.201204868)

A total synthesis of the ammonium ionophore, (-)-enniatin B

DX Hu, M Bielitza, P Koos, SV Ley

Tetrahedron Letters

(2012)

53

4077

(doi: 10.1016/j.tetlet.2012.05.110)

Continuous multiple liquid-liquid separation: diazotization of amino acids in flow.

DX Hu, M O'Brien, SV Ley

Organic letters

(2012)

14

4246

(doi: 10.1021/ol301930h)

A prototype continuous-flow liquid-liquid extraction system using open-source technology.

M O'Brien, P Koos, DL Browne, SV Ley

Organic and Biomolecular Chemistry

(2012)

10

7031

(doi: 10.1039/c2ob25912e)

On being green: Can flow chemistry help?

SV Ley

Chemical Record

(2012)

12

378

(doi: 10.1002/tcr.201100041)

A “Catch–React–Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

RJ Ingham, E Riva, N Nikbin, IR Baxendale, SV Ley

Org Lett

(2012)

14

3920

(doi: 10.1021/ol301673q)

Continuous flow reaction monitoring using an on-line miniature mass spectrometer

DL Browne, S Wright, BJ Deadman, S Dunnage, IR Baxendale, RM Turner, SV Ley

Rapid Commun Mass Spectrom

(2012)

26

1999

(doi: 10.1002/rcm.6312)

Establishing a Flow Process to Coumarin‐8‐Carbaldehydes as Important Synthetic Scaffolds

J Zak, D Ron, E Riva, HP Harding, BCS Cross, IR Baxendale

Chemistry (Weinheim an der Bergstrasse, Germany)

(2012)

18

9901

(doi: 10.1002/chem.201201039)

Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

S Newton, SV Ley, EC Arcé, DM Grainger

Advanced Synthesis and Catalysis

(2012)

354

1805

(doi: 10.1002/adsc.201200073)

Rotamers or diastereomers? An overlooked NMR solution.

DX Hu, P Grice, SV Ley

The Journal of organic chemistry

(2012)

77

5198

(doi: 10.1021/jo300734r)