Professor Steve Ley CBE FRS FMedSci | Page 22 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

RM Myers, KA Roper, IR Baxendale, SV Ley

(2012)

359

(doi: 10.1002/9781118342886.ch11)

Convergent Total Syntheses of Callipeltosides A, B, and C

JR Frost, CM Pearson, TN Snaddon, RA Booth, SV Ley

– Angewandte Chemie (International ed. in English)

(2012)

51,

9366

(doi: 10.1002/anie.201204868)

A total synthesis of the ammonium ionophore, (-)-enniatin B

DX Hu, M Bielitza, P Koos, SV Ley

– Tetrahedron Letters

(2012)

53,

4077

(doi: 10.1016/j.tetlet.2012.05.110)

Continuous Multiple Liquid–Liquid Separation: Diazotization of Amino Acids in Flow

DX Hu, M O'Brien, SV Ley

– Organic letters

(2012)

14,

4246

(doi: 10.1021/ol301930h)

A prototype continuous-flow liquid-liquid extraction system using open-source technology.

M O'Brien, P Koos, DL Browne, SV Ley

– Org Biomol Chem

(2012)

10,

7031

(doi: 10.1039/c2ob25912e)

On being green: Can flow chemistry help?

SV Ley

– Chemical Record

(2012)

12,

378

(doi: 10.1002/tcr.201100041)

A total synthesis of the ammonium ionophore, (−)-enniatin B

DX Hu, M Bielitza, P Koos, SV Ley

– Tetrahedron Letters

(2012)

53,

4077

(doi: 10.1016/j.tetlet.2012.05.110)

A “Catch–React–Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base

RJ Ingham, E Riva, N Nikbin, IR Baxendale, SV Ley

– Org Lett

(2012)

14,

3920

(doi: 10.1021/ol301673q)

Continuous flow reaction monitoring using an on-line miniature mass spectrometer

DL Browne, S Wright, BJ Deadman, S Dunnage, IR Baxendale, RM Turner, SV Ley

– Rapid Commun Mass Spectrom

(2012)

26,

1999

(doi: 10.1002/rcm.6312)

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.

J Zak, D Ron, E Riva, HP Harding, BCS Cross, IR Baxendale

– Chemistry - A European Journal

(2012)

18,

9901

(doi: 10.1002/chem.201201039)