Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib.

BJ Deadman, MD Hopkin, IR Baxendale, SV Ley

Org Biomol Chem

(2012)

11

1766

(doi: 10.1039/c2ob27003j)

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

MD Hopkin, IR Baxendale, SV Ley

Org Biomol Chem

(2012)

11

1822

(doi: 10.1039/c2ob27002a)

Synthesis and use of a trifluoromethylated azomethine ylide precursor.

G Tran, R Meier, L Harris, DL Browne, SV Ley

Journal of Organic Chemistry

(2012)

77

11071

(doi: 10.1021/jo302052m)

Flow microwave technology and microreactors in synthesis

IR Baxendale, C Hornung, SV Ley, J de Mata Muñoz Molina, A Wikström

Australian Journal of Chemistry

(2012)

66

131

(doi: 10.1071/ch12365)

Development of a Phantom to Modulate the Maternal and Fetal Pulse Curve for Pulse Oximetry Measurements

S Weyrich, S Sprenger, M Böttrich, P Schmidt, D Laqua, S Ley, P Husar

Biomedical Engineering / Biomedizinische Technik

(2012)

57

/j/bmte.2012.57.issue-s1-O/bmt-2012-4204/bmt-2012-

(doi: 10.1515/bmt-2012-4204)

Examining basilar membrane motion of an auditory model by using tone-burst otoacoustic emissions.

S Ley, A Chilian, T Harczos, A Katai, F Klefenz, P Husar

Biomed Tech (Berl)

(2012)

57 Suppl 1

/j/bmte.2012.57.issue-s1-O/bmt-2012-4145/bmt-2012-

(doi: 10.1515/bmt-2012-4145)

Synthesis of Enantiomerically Enriched 3-Amino-2-oxindoles through a Palladium-Mediated Asymmetric Intramolecular Arylation of α-Ketimino Amides

P Tolstoy, SXY Lee, C Sparr, SV Ley

Organic letters

(2012)

14

4810

(doi: 10.1021/ol302119j)

High Performance Triple LED Driver with Digitally Controlled Analog Dimming for Reflection Pulse Oximetry

A Hauke, J Krämer, D Laqua, S Ley, P Husar

Biomedical Engineering / Biomedizinische Technik

(2012)

57

580

(doi: 10.1515/bmt-2012-4128)

The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds

RM Myers, KA Roper, IR Baxendale, SV Ley

(2012)

359

(doi: 10.1002/9781118342886.ch11)

Convergent Total Syntheses of Callipeltosides A, B, and C

JR Frost, CM Pearson, TN Snaddon, RA Booth, SV Ley

Angewandte Chemie (International ed. in English)

(2012)

51

9366

(doi: 10.1002/anie.201204868)