Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1
Chemistry - A European Journal
(2013)
19
7917
(doi: 10.1002/chem.201300696)
A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia
Org Lett
(2013)
15
2278
(doi: 10.1021/ol400856g)
Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low-Temperature Flow Processes
Chemical Engineering and Technology
(2013)
36
959
(doi: 10.1002/ceat.201200581)
Synthesis of spongistatin 2 employing a new route to the EF fragment
Chemical Science
(2013)
4
1989
(doi: 10.1039/c3sc50304f)
The integration of flow reactors into synthetic organic chemistry
Journal of Chemical Technology & Biotechnology
(2013)
88
519
(doi: 10.1002/jctb.4012)
Synthesis of (-)-hennoxazole A: Integrating batch and flow chemistry methods
Synlett
(2013)
24
514
(doi: 10.1055/s-0032-1318109)
Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography
Chemical Science
(2013)
4
764
(doi: 10.1039/c2sc21850j)
A Continuous Flow Solution to Achieving Efficient Aerobic Anti-Markovnikov Wacker Oxidation
Advanced Synthesis and Catalysis
(2013)
342
A prototype device for evaporation in batch and flow chemical processes
Green Chemistry
(2013)
15
2050
(doi: 10.1039/c3gc40967h)
Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes
Chemcatchem
(2012)
5
159
(doi: 10.1002/cctc.201200778)
- ‹ previous
- Page 20
