Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The rapid generation of isothiocyanates in flow.
Beilstein J Org Chem
(2013)
9
1613
(doi: 10.3762/bjoc.9.184)
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
Bioorganic and Medicinal Chemistry
(2013)
21
4378
(doi: 10.1016/j.bmc.2013.04.075)
A Continuous Flow Solution to Achieving Efficient Aerobic Anti‐Markovnikov Wacker Oxidation
Advanced Synthesis and Catalysis
(2013)
355
1905
(doi: 10.1002/adsc.201300278)
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release
ACS Medicinal Chemistry Letters
(2013)
4
704
(doi: 10.1021/ml400079h)
Camera-enabled techniques for organic synthesis.
Beilstein journal of organic chemistry
(2013)
9
1051
(doi: 10.3762/bjoc.9.118)
Flow chemistry approaches directed at improving chemical synthesis
gps
(2013)
2
211
(doi: 10.1515/gps-2013-0029)
Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor
Synlett
(2013)
24
1298
(doi: 10.1055/s-0033-1338455)
A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2013)
19
7917
(doi: 10.1002/chem.201300696)
A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia
Organic letters
(2013)
15
2278
(doi: 10.1021/ol400856g)
Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low‐Temperature Flow Processes
Chemical Engineering & Technology
(2013)
36
959
(doi: 10.1002/ceat.201200581)
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