Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen

PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley

Organic Process Research & Development

(2013)

1192

(doi: 10.1021/op4001548)

Flow chemistry syntheses of natural products

JC Pastre, DL Browne, SV Ley

Chem Soc Rev

(2013)

8849

(doi: 10.1039/c3cs60246j)

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.

KA Roper, MB Berry, SV Ley

Beilstein Journal of Organic Chemistry

(2013)

1781

(doi: 10.3762/bjoc.9.207)

Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia

JC Pastre, DL Browne, M O’Brien, SV Ley

Organic Process Research and Development

(2013)

1183

(doi: 10.1021/op400152r)

The rapid generation of isothiocyanates in flow.

M Baumann, IR Baxendale

Beilstein J Org Chem

(2013)

1613

(doi: 10.3762/bjoc.9.184)

The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

IR Baxendale, S Cheung, MO Kitching, SV Ley, JW Shearman

Bioorganic and Medicinal Chemistry

(2013)

4378

(doi: 10.1016/j.bmc.2013.04.075)

A Continuous Flow Solution to Achieving Efficient Aerobic Anti‐Markovnikov Wacker Oxidation

SL Bourne, SV Ley

Advanced Synthesis & Catalysis

(2013)

355

1905

(doi: 10.1002/adsc.201300278)

Flow synthesis and biological studies of an analgesic adamantane derivative that inhibits P2X7-evoked glutamate release

C Battilocchio, L Guetzoyan, C Cervetto, L Di Cesare Mannelli, D Frattaroli, IR Baxendale, G Maura, A Rossi, L Sautebin, M Biava, C Ghelardini, M Marcoli, SV Ley

ACS Med Chem Lett

(2013)

704

(doi: 10.1021/ml400079h)