Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Living with our machines: Towards a more sustainable future

SV Ley, Y Chen, DE Fitzpatrick, OS May

Current Opinion in Green and Sustainable Chemistry

(2020)

25

100353

(doi: 10.1016/j.cogsc.2020.100353)

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin

J Pastre, P Murray, D Browne, G Brancaglion, R Galaverna, R Pilli, SV Ley

ACS Omega

(2020)

5

18472

(doi: 10.1021/acsomega.0c02390)

In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions

L Cao, M Kabeshov, SV Ley, AA Lapkin

Beilstein Journal of Organic Chemistry

(2020)

16

1465

(doi: 10.3762/bjoc.16.122)

Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins.

SV Ley, Y Chen, N McNamara, O May, T Pillaiyara, D Blakemore

Organic letters

(2020)

22

5746

(doi: 10.1021/acs.orglett.0c01730)

In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions

L Cao, M Kabeshov, S Ley, A Lapkin

(2020)

(doi: 10.26434/chemrxiv.11961354.v2)

In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions

L Cao, M Kabeshov, S Ley, A Lapkin

(2020)

(doi: 10.26434/chemrxiv.11961354.v1)

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions

DE Fitzpatrick, M O'Brien, SV Ley

Reaction Chemistry & Engineering

(2020)

5

201

(doi: 10.1039/c9re00407f)

A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters

E Watanabe, Y Chen, O May, SV Ley

Chemistry: A European Journal

(2019)

26

186

(doi: 10.1002/chem.201905048)

Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source

P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza

Journal of Organic Chemistry

(2019)

84

14394

(doi: 10.1021/acs.joc.9b02453)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

S Roy, J Sipthorp, B Mahata, J Pramanik, ML Hennrich, A-C Gavin, SV Ley, SA Teichmann

(2019)

(doi: 10.1101/800649)