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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Living with our machines: Towards a more sustainable future
SV Ley, Y Chen, DE Fitzpatrick, OS May
– Current Opinion in Green and Sustainable Chemistry
(2020)
25,
100353
(doi: 10.1016/j.cogsc.2020.100353)
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin.
J Pastre, P Murray, D Browne, G Brancaglion, R Galaverna, R Pilli, SV Ley
– ACS omega
(2020)
5,
18472
(doi: 10.1021/acsomega.0c02390)
In silico rationalisation of selectivity and reactivity in Pd-catalysed C-H activation reactions
L Cao, M Kabeshov, SV Ley, AA Lapkin
– Beilstein journal of organic chemistry
(2020)
16,
1465
(doi: 10.3762/bjoc.16.122)
Photoredox generation of sulfonyl radicals and coupling with electron deficient olefins
SV Ley, Y Chen, N McNamara, O May, T Pillaiyara, D Blakemore
– Org Lett
(2020)
22,
5746
(doi: 10.1021/acs.orglett.0c01730)
In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions
L Cao, M Kabeshov, S Ley, A Lapkin
(2020)
(doi: 10.26434/chemrxiv.11961354.v2)
In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions
L Cao, M Kabeshov, S Ley, A Lapkin
(2020)
(doi: 10.26434/chemrxiv.11961354.v1)
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
DE Fitzpatrick, M O'Brien, SV Ley
– Reaction Chemistry and Engineering
(2020)
5,
201
(doi: 10.1039/c9re00407f)
A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters
E Watanabe, Y Chen, O May, SV Ley
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2019)
26,
186
(doi: 10.1002/chem.201905048)
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– J Org Chem
(2019)
84,
14394
(doi: 10.1021/acs.joc.9b02453)
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
S Roy, J Sipthorp, B Mahata, J Pramanik, M Hennrich, A-C Gavin, S Ley, S Teichmann
(2019)
(doi: 10.1101/800649)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge