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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions
L Cao, M Kabeshov, S Ley, A Lapkin
(2020)
(doi: 10.26434/chemrxiv.11961354.v1)
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
DE Fitzpatrick, M O'Brien, SV Ley
– Reaction Chemistry and Engineering
(2020)
5,
201
(doi: 10.1039/c9re00407f)
A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.
E Watanabe, Y Chen, O May, SV Ley
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2019)
26,
186
(doi: 10.1002/chem.201905048)
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– J Org Chem
(2019)
84,
14394
(doi: 10.1021/acs.joc.9b02453)
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
S Roy, J Sipthorp, B Mahata, J Pramanik, M Hennrich, A-C Gavin, S Ley, S Teichmann
(2019)
(doi: 10.1101/800649)
A New World for Chemical Synthesis?
S Ley, Y Chen, D Fitzpatrick, O May
– CHIMIA International Journal for Chemistry
(2019)
73,
792
(doi: 10.2533/chimia.2019.792)
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
Y Chen, O May, DC Blakemore, SV Ley
– Organic letters
(2019)
21,
6140
(doi: 10.1021/acs.orglett.9b02307)
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.
R Grainger, TD Heightman, SV Ley, F Lima, CN Johnson
– Chem Sci
(2019)
10,
2264
(doi: 10.1039/C8SC04789H)
Direct Oxidation of Csp3−H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow
M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2019)
25,
1203
(doi: 10.1002/chem.201805657)
Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol
R Labes, C Mateos, C Battilocchio, Y Chen, P Dingwall, GR Cumming, JA Rincón, MJ Nieves-Remacha, SV Ley
– Green Chemistry
(2019)
21,
59
(doi: 10.1039/c8gc03328e)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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