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Professor Steve Ley CBE FRS FMedSci

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In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

For more detailed research information, group members and our publication list please see the group website (Whiffen Lab and ITC)


Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
C Battilocchio, G Iannucci, S Wang, E Godineau, A Kolleth, A De Mesmaeker, SV Ley
– React. Chem. Eng.
Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform
DE Fitzpatrick, SV Ley
– React. Chem. Eng.
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp 2 )-C(sp 3 ) Cross-Couplings in Flow
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angewandte Chemie
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp(2) )-C(sp(3) ) Cross-Couplings in Flow.
F Lima, MA Kabeshov, DN Tran, C Battilocchio, J Sedelmeier, G Sedelmeier, B Schenkel, SV Ley
– Angew Chem Int Ed Engl
Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff-Staudinger Cascade Reaction
B Musio, F Mariani, EP Śliwiński, MA Kabeshov, H Odajima, SV Ley
– Synthesis (Germany)
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
S Picaud, K Leonards, J-P Lambert, O Dovey, C Wells, O Fedorov, O Monteiro, T Fujisawa, C-Y Wang, H Lingard, C Tallant, N Nikbin, L Guetzoyan, R Ingham, SV Ley, P Brennan, S Muller, A Samsonova, A-C Gingras, J Schwaller, G Vassiliou, S Knapp, P Filippakopoulos
– Sci Adv
Continuous Processing and Efficient in Situ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
B Ahmed-Omer, E Sliwinski, JP Cerroti, SV Ley
– Organic Process Research and Development
The Total Synthesis of the Bioactive Natural Product PlantazolicinA and Its Biosynthetic Precursor PlantazolicinB
S Fenner, ZE Wilson, SV Ley
– Chemistry
Flow Chemistry in Europe
V Hessel, SV Ley
– Journal of Flow Chemistry
Taming hazardous chemistry by continuous flow technology
M Movsisyan, EIP Delbeke, JKET Berton, C Battilocchio, SV Ley, CV Stevens
– Chemical Society reviews
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01223 336398

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