Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation.

SL Bourne, F Amann, SV Ley

CHIMIA International Journal for Chemistry

(2023)

77

288

(doi: 10.2533/chimia.2023.288)

Exploring the chemical space of phenyl sulfide oxidation by automated optimization

P Mueller, A Vriza, AD Clayton, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne

Reaction Chemistry & Engineering

(2023)

8

538

(doi: 10.1039/d2re00552b)

Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis

OM Griffiths, SV Ley

The Journal of Organic Chemistry

(2022)

87

13204

(doi: 10.1021/acs.joc.2c01684)

Automated multi-objective reaction optimisation: which algorithm should I use?

P Müller, AD Clayton, J Manson, S Riley, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne

Reaction Chemistry & Engineering

(2022)

7

987

(doi: 10.1039/d1re00549a)

Flow Chemistry – Applications

F Darvas, G Dormán, V Hessel, SV Ley

(2021)

1

(doi: 10.1515/9783110693690)

Outlook, future directions, and emerging applications

SV Ley, OS May, OM Griffiths, K Sowa

(2021)

313

(doi: 10.1515/9783110693690-011)

Flow Chemistry – Fundamentals

F Darvas, G Dormán, V Hessel, SV Ley

(2021)

1

1

(doi: 10.1515/9783110693676)

Photoredox-Catalyzed Dehydrogenative Csp³–Csp² Cross-Coupling of Alkylarenes to Aldehydes in Flow

OM Griffiths, HA Esteves, Y Chen, K Sowa, OS May, P Morse, DC Blakemore, SV Ley

J Org Chem

(2021)

86

13559

(doi: 10.1021/acs.joc.1c01621)

Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

HR Smallman, JA Leitch, T McBride, SV Ley, DL Browne

Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr

(2021)

93

132305

(doi: 10.1016/j.tet.2021.132305)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.

S Roy, J Sipthorp, B Mahata, J Pramanik, ML Hennrich, A-C Gavin, SV Ley, SA Teichmann

iScience

(2021)

24

102485

(doi: 10.1016/j.isci.2021.102485)