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Department of Chemistry

Portrait of svl1000

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.


Direct Oxidation of Csp3−H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow
M Lesieur, C Battilocchio, R Labes, J Jacq, C Genicot, SV Ley, P Pasau
– Chemistry
Fast continuous alcohol amination employing a hydrogen borrowing protocol
R Labes, C Mateos, C Battilocchio, Y Chen, P Dingwall, GR Cumming, JA Rincón, MJ Nieves-Remacha, SV Ley
– Green Chemistry
Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow
Y Chen, M Leonardi, P Dingwall, R Labes, P Pasau, DC Blakemore, SV Ley
– Journal of Organic Chemistry
Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.
DE Fitzpatrick, T Maujean, AC Evans, SV Ley
– Angew Chem Int Ed Engl
Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server
DE Fitzpatrick, T Maujean, AC Evans, SV Ley
– Angewandte Chemie
Three-component assembly of multiply-substituted homoallylic alcohols and amines using a flow chemistry photoreactor
Y Chen, DC Blakemore, P Pasau, SV Ley
– Organic Letters
In- line separation of multicomponent reaction mixtures using a new semi- continuous supercritical fluid chromatography system
DE Fitzpatrick, RJ Mutton, SV Ley
– Reaction Chemistry and Engineering
Integrated plug flow synthesis and crystallisation of pyrazinamide
C Daniel Scott, R Labes, M Depardieu, C Battilocchio, MG Davidson, SV Ley, CC Wilson, K Robertson
– Reaction Chemistry and Engineering
Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone
M O'Brien, A Weber, G Hardy, SV Ley
– Tetrahedron
A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
SV Ley, E Godineau, C Battilocchio, M Lehmann, R Labes, L Birnoschi, S Subramanian, CS Prasanna, A Gorde, M Kalbagh, V Khade, A Scherrer, AC O'Sullivan
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01223 336398

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