Professor Steve Ley CBE FRS FMedSci | Page 2 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Multicomponent Direct Assembly of N‑Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis

OM Griffiths, SV Ley

– J Org Chem

(2022)

87,

13204

(doi: 10.1021/acs.joc.2c01684)

Automated multi-objective reaction optimisation: which algorithm should I use?

P Müller, AD Clayton, J Manson, S Riley, OS May, N Govan, S Notman, SV Ley, TW Chamberlain, RA Bourne

– Reaction Chemistry & Engineering

(2022)

7,

987

(doi: 10.1039/d1re00549a)

11 Outlook, future directions, and emerging applications

SV Ley, OS May, OM Griffiths, K Sowa

(2021)

313

(doi: 10.1515/9783110693690-011)

Flow Chemistry – Fundamentals

F Darvas, G Dormán, V Hessel, SV Ley

(2021)

1,

1

(doi: 10.1515/9783110693676)

Flow Chemistry – Applications

F Darvas, G Dormán, V Hessel, SV Ley

(2021)

1

(doi: 10.1515/9783110693690)

Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow

OM Griffiths, HA Esteves, Y Chen, K Sowa, OS May, P Morse, DC Blakemore, SV Ley

– Journal of Organic Chemistry

(2021)

86,

13559

(doi: 10.1021/acs.joc.1c01621)

Formation and utility of reactive ketene intermediates under continuous flow conditions

HR Smallman, JA Leitch, T McBride, SV Ley, DL Browne

– Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr

(2021)

93,

132305

(doi: 10.1016/j.tet.2021.132305)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.

S Roy, J Sipthorp, B Mahata, J Pramanik, ML Hennrich, A-C Gavin, SV Ley, SA Teichmann

– iScience

(2021)

24,

102485

(doi: 10.1016/j.isci.2021.102485)

A Comment on Continuous Flow Technologies within the Agrochemical Industry

SV Ley, Y Chen, A Robinson, B Otter, E Godineau, C Battilocchio

– Organic Process Research & Development

(2021)

25,

713

(doi: 10.1021/acs.oprd.0c00534)

Living with our machines: Towards a more sustainable future

SV Ley, Y Chen, DE Fitzpatrick, OS May

– Current Opinion in Green and Sustainable Chemistry

(2020)

25,

100353

(doi: 10.1016/j.cogsc.2020.100353)