Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
In silico rationalisation of selectivity and reactivity in Pd-catalysed C-H activation reactions.
– Beilstein journal of organic chemistry
(2020)
16,
1465
(doi: 10.3762/bjoc.16.122)
Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins
– Org Lett
(2020)
22,
5746
(doi: 10.1021/acs.orglett.0c01730)
In Silico Rationalisation of Selectivity and Reactivity in Pd-Catalysed C-H Activation Reactions
(2020)
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
– Reaction Chemistry & Engineering
(2020)
5,
201
(doi: 10.1039/c9re00407f)
A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2019)
26,
186
(doi: 10.1002/chem.201905048)
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.
– Journal of Organic Chemistry
(2019)
84,
14394
(doi: 10.1021/acs.joc.9b02453)
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow.
– Org Lett
(2019)
21,
6140
(doi: 10.1021/acs.orglett.9b02307)
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.
– Chemical science
(2019)
10,
2264
(doi: 10.1039/c8sc04789h)
Direct Oxidation of Csp3 -H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow.
– Chemistry
(2019)
25,
1203
(doi: 10.1002/chem.201805657)
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